%0 Journal Article
%A Lopez-Mejias, Raquel
%A Carmona, F David
%A Genre, Fernanda
%A Remuzgo-Martinez, Sara
%A Gonzalez-Juanatey, Carlos
%A Corrales, Alfonso
%A Vicente, Esther F
%A Pulito-Cueto, Veronica
%A Miranda-Filloy, Jose A
%A Ramirez-Huaranga, Marco A
%A Blanco, Ricardo
%A Robustillo-Villarino, Montserrat
%A Rodriguez-Carrio, Javier
%A Alperi-Lopez, Mercedes
%A Alegre-Sancho, Juan J
%A Mijares, Veronica
%A Lera-Gomez, Leticia
%A Perez-Pampin, Eva
%A Gonzalez, Antonio
%A Ortega-Castro, Rafaela
%A Lopez-Pedrera, Chary
%A Garcia-Vivar, Mari L
%A Gomez-Arango, Catalina
%A Raya, Enrique
%A Narvaez, Javier
%A Balsa, Alejandro
%A Lopez-Longo, Francisco J
%A Carreira, Patricia
%A Gonzalez-Alvaro, Isidoro
%A Rodriguez-Rodriguez, Luis
%A Fernandez-Gutierrez, Benjamin
%A Ferraz-Amaro, Iván
%A Gualillo, Oreste
%A Castañeda, Santos
%A Martin, Javier
%A Llorca, Javier
%A Gonzalez-Gay, Miguel A
%T Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study.
%D 2018
%U http://hdl.handle.net/10668/12993
%X To investigate the genetic background influencing the development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA). We performed a genome-wide association study (GWAS) in which, after quality control and imputation, a total of 6,308,944 polymorphisms across the whole genome were analyzed in 2,989 RA patients of European origin. Data on subclinical atherosclerosis, obtained through assessment of carotid intima-media thickness (CIMT) and presence/absence of carotid plaques by carotid ultrasonography, were available for 1,355 individuals. A genetic variant of the RARB gene (rs116199914) was associated with CIMT values at the genome-wide level of significance (minor allele [G] β coefficient 0.142, P = 1.86 × 10-8 ). Interestingly, rs116199914 overlapped with regulatory elements in tissues related to CV pathophysiology and immune cells. In addition, biologic pathway enrichment and predictive protein-protein relationship analyses, including suggestive GWAS signals of potential relevance, revealed a functional enrichment of the collagen biosynthesis network related to the presence/absence of carotid plaques (Gene Ontology no. 0032964; false discovery rate-adjusted P = 4.01 × 10-3 ). Furthermore, our data suggest potential influences of the previously described candidate CV risk loci NFKB1, MSRA, and ZC3HC1 (P = 8.12 × 10-4 , P = 5.94 × 10-4 , and P = 2.46 × 10-4 , respectively). The present findings strongly suggest that genetic variation within RARB contributes to the development of subclinical atherosclerosis in patients with RA.
%K 3' Untranslated Regions
%K Adaptor Proteins, Signal Transducing
%K Arthritis, Rheumatoid
%K Atherosclerosis
%K Carotid Arteries
%K Carotid Intima-Media Thickness
%~