RT Journal Article
T1 New hPSC-based human models to study pediatric Acute Megakaryoblastic Leukemia harboring the fusion oncogene RBM15-MKL1.
A1 Ayllón, Verónica
A1 Vogel-González, Marina
A1 González-Pozas, Federico
A1 Domingo-Reinés, Joan
A1 Montes, Rosa
A1 Morales-Cacho, Lucía
A1 Ramos-Mejía, Verónica
AB Pediatric Acute Megakaryoblastic Leukemia not associated to Down Syndrome (non-DS AMKL) is a rare disease with a dismal prognosis. Around 15% of patients carry the chromosomal translocation t(1;22) that originates the fusion oncogene RBM15-MKL1, which is linked to an earlier disease onset (median of 6months of age) and arises in utero. Here we report the generation of two hPSC cell lines constitutively expressing the oncogene RBM15-MKL1, resulting in an increased expression of known RBM15-MKL1 gene targets. These cell lines represent new disease models of pediatric AMKL to study the impact of the RBM15-MKL1 oncogene on human embryonic hematopoietic development.
YR 2016
FD 2016-12-19
LK http://hdl.handle.net/10668/11099
UL http://hdl.handle.net/10668/11099
LA en
DS RISalud
RD Apr 5, 2025