TY  - JOUR
AU  - Muñoz-Galván, Sandra
AU  - Felipe-Abrio, Blanca
AU  - Verdugo-Sivianes, Eva M.
AU  - Perez, Marco
AU  - Jiménez-García, Manuel P.
AU  - Suarez-Martinez, Elisa
AU  - Estevez-Garcia, Purificacion
AU  - Carnero, Amancio
PY  - 2020
DO  - 10.1186/s12943-020-1130-z
UR  - http://hdl.handle.net/10668/4330
T2  - Molecular Cancer
AB  - Background: Ovarian cancer is one of the most common and malignant cancers, partly due to its late diagnosis and high recurrence. Chemotherapy resistance has been linked to poor prognosis and is believed to be linked to the cancer stem cell (CSC)...
LA  - en
PB  - BioMed Central, Springer Nature
KW  - Ovarian cancer
KW  - MYPT1 (PPP1R12A)
KW  - MiR-30b
KW  - Therapy resistance
KW  - Hippo pathway
KW  - Stemness
KW  - Cisplatin
KW  - Chemotherapy
KW  - Neoplasias ováricas
KW  - Vía de señalización hippo
KW  - Cisplatino
KW  - Quimioterapia
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Growth::Cell Growth Processes::Cell Proliferation
KW  - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Platinum Compounds::Cisplatin
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Nude
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Invasiveness
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local
KW  - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Rate
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Tumor Cells, Cultured
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Drug Evaluation, Preclinical::Drug Screening Assays, Antitumor::Xenograft Model Antitumor Assays
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm
TI  - Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness
TY  - research article
ER  -