RT Journal Article
T1 Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals.
A1 Roc, Lourdes
A1 de Mendoza, Carmen
A1 Fernández-Alonso, Miriam
A1 Reina, Gabriel
A1 Soriano, Vicente
A1 Spanish HTLV Network, 
K1 HTLV-1
K1 antiretroviral drugs
K1 myelopathy
K1 screening
K1 transplantation
AB Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor-recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
SN 2049-9361
YR 2019
FD 2019-08-21
LK https://hdl.handle.net/10668/27714
UL https://hdl.handle.net/10668/27714
LA en
DS RISalud
RD Apr 8, 2025