RT Journal Article
T1 Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
A1 Gerussi, Alessio
A1 Natalini, Ambra
A1 Antonangeli, Fabrizio
A1 Mancuso, Clara
A1 Agostinetto, Elisa
A1 Barisani, Donatella
A1 Di Rosa, Francesca
A1 Andrade, Raul
A1 Invernizzi, Pietro
K1 Inflammation
K1 Autoimmune hepatitis
K1 Autoimmunity
K1 Genetics
K1 Drug-induced liver injury
K1 Inflammation
K1 Hepatitis autoinmune
K1 Autoimmunity
K1 Genética
K1 Enfermedad hepática inducida por sustancias y drogas
K1 Inflamación
AB Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.
PB MDPI
YR 2021
FD 2021-04-27
LK http://hdl.handle.net/10668/3615
UL http://hdl.handle.net/10668/3615
LA en
NO Gerussi A, Natalini A, Antonangeli F, Mancuso C, Agostinetto E, Barisani D, et al. Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models. Int J Mol Sci. 2021 Apr 27;22(9):4557
DS RISalud
RD Apr 6, 2025