RT Journal Article
T1 Pregnancy outcomes in mixed connective tissue disease: a multicentre study.
A1 Radin, Massimo
A1 Schreiber, Karen
A1 Cuadrado, Maria Jose
A1 Cecchi, Irene
A1 Andreoli, Laura
A1 Franceschini, Franco
A1 Caleiro, Teresa
A1 Andrade, Danieli
A1 Gibbone, Elena
A1 Khamashta, Munther
A1 Buyon, Jill
A1 Izmirly, Peter
A1 Aguirre, Maria Angeles
A1 Benedetto, Chiara
A1 Roccatello, Dario
A1 Marozio, Luca
A1 Sciascia, Savino
K1 Anti-U1RNP
K1 Antibodies
K1 Autoimmune disease
K1 Congenital heart block
K1 Mixed connective tissue disease
K1 Neonatal lupus
K1 Pregnancy
K1 Pregnancy complications
AB In this study we aimed to investigate foetal and maternal pregnancy outcomes from a large multicentre cohort of women diagnosed with MCTD and anti-U1RNP antibodies. This multicentre retrospective cohort study describes the outcomes of 203 pregnancies in 94 consecutive women ever pregnant who fulfilled the established criteria for MCTD with confirmed U1RNP positivity. The foetal outcomes in 203 pregnancies were as follows: 146 (71.9%) live births, 38 (18.7%) miscarriages (first trimester pregnancy loss of  In our multicentre cohort, women with MCTD had a live birth rate of 72%. While the true frequency of heart block associated with anti-U1RNP remains to be determined, this study might raise the consideration of echocardiographic surveillance in this setting. Pregnancy counselling should be considered in women with MCTD.
PB Oxford University Press
YR 2019
FD 2019-03-17
LK http://hdl.handle.net/10668/13943
UL http://hdl.handle.net/10668/13943
LA en
NO Radin M, Schreiber K, Cuadrado MJ, Cecchi I, Andreoli L, Franceschini F, et al. Pregnancy outcomes in mixed connective tissue disease: a multicentre study. Rheumatology (Oxford). 2019 Nov 1;58(11):2000-2008
DS RISalud
RD Apr 17, 2025