RT Journal Article
T1 The complex three-dimensional organization of epithelial tissues.
A1 Gómez-Gálvez, Pedro
A1 Vicente-Munuera, Pablo
A1 Anbari, Samira
A1 Buceta, Javier
A1 Escudero, Luis M
K1 Apico-basal cell intercalation
K1 Biophysical modeling
K1 Cell shape
K1 Mathematical modeling
K1 Scutoid
K1 Three-dimensional cell packing
AB Understanding the cellular organization of tissues is key to developmental biology. In order to deal with this complex problem, researchers have taken advantage of reductionist approaches to reveal fundamental morphogenetic mechanisms and quantitative laws. For epithelia, their two-dimensional representation as polygonal tessellations has proved successful for understanding tissue organization. Yet, epithelial tissues bend and fold to shape organs in three dimensions. In this context, epithelial cells are too often simplified as prismatic blocks with a limited plasticity. However, there is increasing evidence that a realistic approach, even from a reductionist perspective, must include apico-basal intercalations (i.e. scutoidal cell shapes) for explaining epithelial organization convincingly. Here, we present an historical perspective about the tissue organization problem. Specifically, we analyze past and recent breakthroughs, and discuss how and why simplified, but realistic, in silico models require scutoidal features to address key morphogenetic events.
YR 2021
FD 2021-01-06
LK http://hdl.handle.net/10668/16932
UL http://hdl.handle.net/10668/16932
LA en
DS RISalud
RD Apr 20, 2025