TY - JOUR AU - Pellegrinelli, V AU - Rodriguez-Cuenca, S AU - Rouault, C AU - Figueroa-Juarez, E AU - Schilbert, H AU - Virtue, S AU - Moreno-Navarrete, J M AU - Bidault, G AU - Vazquez-Borrego, M C AU - Dias, A R AU - Pucker, B AU - Dale, M AU - Campbell, M AU - Carobbio, S AU - Lin, Y H AU - Vacca, M AU - Aron-Wisnewsky, J AU - Mora, S AU - Masiero, M M AU - Emmanouilidou, A AU - Mukhopadhyay, S AU - Dougan, G AU - den Hoed, M AU - Loos, R J F AU - Fernandez-Real, J M AU - Chiarugi, D AU - Clement, K AU - Vidal-Puig, A PY - 2022 DO - 10.1038/s42255-022-00561-5 UR - http://hdl.handle.net/10668/19638 T2 - Nature metabolism AB - Resulting from impaired collagen turnover, fibrosis is a hallmark of adipose tissue (AT) dysfunction and obesity-associated insulin resistance (IR). Prolidase, also known as peptidase D (PEPD), plays a vital role in collagen turnover by degrading... LA - en PB - Nature Publishing Group KW - Adipose tissue KW - Animals KW - Diabetes mellitus, type 2 KW - Dipeptidases KW - Fibrosis KW - Inflammation KW - Insulin resistance KW - Macrophages KW - Mice KW - Obesity TI - Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. TY - Research article VL - 4 ER -