RT Journal Article
T1 Killer immunoglobulin-like receptor and cancer
A1 Maria Gomez-Luque, Jose
A1 Urrutia-Maldonado, Emilia
A1 Munoz de Rueda, Paloma
A1 Abril-Molina, Ana
A1 Ocete-Hita, Esther
K1 NK cells immunoglobulin-like receptor
K1 Genotype
K1 Cancer
K1 Pediatrics
K1 Acute lymphoblastic-leukemia
K1 Cell receptors
K1 Hla
K1 Genes
K1 Kir
K1 Susceptibility
K1 Ligands
K1 Associations
K1 Diversity
AB Introduction: Natural killer (NK) cells play an important role in defense against tumor cells. The development and function of NK cells is governed by a dynamic balance between inhibition and activation of cell surface receptors, including KIR receptors.Patients and method: A case-control study is carried out that compares a group of 46 children diagnosed with malignant diseases, the control group is made up of 82 healthy children. KIRs genes, haplotypes and ligands were determined and compared between groups.Results: There are no differences in KIRs genes, KIRs haplotypes or in KIRs gene ligands between groups. However, when KIRS and ligands were jointly studied, k2DS1 C2 was significantly higher in the group of cancer children (p = 0.016).Conclusions: Our results do not provide evidence of an association between pediatric cancer disease with genotypes and groups of genes KIRs. The k2DS1 C2 genotype could predispose to susceptibility to malignant processes in children. (c) 2021 Published by Elsevier Espana, S.L.U. on behalf of Asociacion Espanola de Pediatria. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
PB Ediciones doyma s a
SN 1695-4033
YR 2022
FD 2022-05-14
LK http://hdl.handle.net/10668/21938
UL http://hdl.handle.net/10668/21938
LA es
DS RISalud
RD Apr 6, 2025