RT Journal Article
T1 Clinical and therapeutic features of myasthenia gravis in adults based on age at onset.
A1 Cortes-Vicente, Elena
A1 Alvarez-Velasco, Rodrigo
A1 Segovia, Sonia
A1 Paradas, Carmen
A1 Casasnovas, Carlos
A1 Guerrero-Sola, Antonio
A1 Pardo, Julio
A1 Ramos-Fransi, Alba
A1 Sevilla, Teresa
A1 Lopez-de-Munain, Adolfo
A1 Gomez, Maria Teresa
A1 Jerico, Ivonne
A1 Gutierrez-Gutierrez, Gerardo
A1 Pelayo-Negro, Ana Lara
A1 Martin, Maria Asuncion
A1 Mendoza, Maria Dolores
A1 Moris, German
A1 Rojas-Garcia, Ricard
A1 Diaz-Manera, Jordi
A1 Querol, Luis
A1 Gallardo, Eduard
A1 Velez, Beatriz
A1 Alberti, Maria Antonia
A1 Galan, Luciía
A1 Garcia-Sobrino, Tania
A1 Martinez-Piñeiro, Alicia
A1 Lozano-Veintimilla, Ana
A1 Fernandez-Torron, Roberto
A1 Cano-Abascal, Angel
A1 Illa, Isabel
K1 Age of Onset
K1 Female
K1 Male
K1 Myasthenia Gravis
AB To describe the characteristics of patients with very-late-onset myasthenia gravis (MG). This observational cross-sectional multicenter study was based on information in the neurologist-driven Spanish Registry of Neuromuscular Diseases (NMD-ES). All patients were >18 years of age at onset of MG and onset occurred between 2000 and 2016 in all cases. Patients were classified into 3 age subgroups: early-onset MG (age at onset 18 years of age at onset of MG and onset occurred between 2000 and 2016 in all cases. Patients were classified into 3 age subgroups: early-onset MG (age at onset  A total of 939 patients from 15 hospitals were included: 288 (30.7%) had early-onset MG, 227 (24.2%) late-onset MG, and 424 (45.2%) very-late-onset MG. The mean follow-up was 9.1 years (SD 4.3). Patients with late onset and very late onset were more frequently men (p  Patients with MG are primarily ≥65 years of age with anti-AChR antibodies and no thymoma. Although patients with very-late-onset MG may present life-threatening events at onset, they achieve a good outcome with fewer immunosuppressants when diagnosed and treated properly.
PB Wolters Kluwer Health
YR 2020
FD 2020-02-18
LK http://hdl.handle.net/10668/15126
UL http://hdl.handle.net/10668/15126
LA en
NO Cortés-Vicente E, Álvarez-Velasco R, Segovia S, Paradas C, Casasnovas C, Guerrero-Sola A, et al. Clinical and therapeutic features of myasthenia gravis in adults based on age at onset. Neurology. 2020 Mar 17;94(11):e1171-e1180.
DS RISalud
RD Apr 19, 2025