RT Journal Article
T1 The association between dietary energy density and type 2 diabetes in Europe: results from the EPIC-InterAct Study
A1 van den Berg, Saskia W.
A1 van der A, Daphne L.
A1 Spijkerman, Annemieke M. W.
A1 van Woudenbergh, Geertruida J.
A1 Tijhuis, Mariken J.
A1 Amiano, Pilar
A1 Ardanaz, Eva
A1 Beulens, Joline W. J.
A1 Boeing, Heiner
A1 Clavel-Chapelon, Françoise
A1 Crowe, Francesca L.
A1 de Lauzon-Guillain, Blandine
A1 Fagherazzi, Guy
A1 Franks, Paul W.
A1 Freisling, Heinz
A1 Gonzalez, Carlos
A1 Grioni, Sara
A1 Halkjaer, Jytte
A1 Huerta, José María
A1 Huybrechts, Inge
A1 Kaaks, Rudolf
A1 Khaw, Kay Tee
A1 Masala, Giovanna
A1 Nilsson, Peter M.
A1 Overvad, Kim
A1 Panico, Salvatore
A1 Quirós, J. Ramón
A1 Rolandsson, Olov
A1 Sacerdote, Carlotta
A1 Sanchez-Perez, Maria-Jose
A1 Schulze, Matthias B.
A1 Slimani, Nadia
A1 Struijk, Ellen A.
A1 Tjonneland, Anne
A1 Tumino, Rosario
A1 Sharp, Stephen J.
A1 Langenberg, Claudia
A1 Forouhi, Nita G.
A1 Feskens, Edith J. M.
A1 Riboli, Elio
A1 Wareham, Nicholas J.
K1 Estudios de casos y controles
K1 Diabetes Mellitus Tipo 2
K1 Dieta
K1 Ingestión de energía
K1 Europa
K1 Humanos
K1 Factores de riesgo
AB BACKGROUNDObservational studies implicate higher dietary energy density (DED) as a potential risk factor for weight gain and obesity. It has been hypothesized that DED may also be associated with risk of type 2 diabetes (T2D), but limited evidence exists. Therefore, we investigated the association between DED and risk of T2D in a large prospective study with heterogeneity of dietary intake.METHODOLOGY/PRINCIPAL FINDINGSA case-cohort study was nested within the European Prospective Investigation into Cancer (EPIC) study of 340,234 participants contributing 3.99 million person years of follow-up, identifying 12,403 incident diabetes cases and a random subcohort of 16,835 individuals from 8 European countries. DED was calculated as energy (kcal) from foods (except beverages) divided by the weight (gram) of foods estimated from dietary questionnaires. Prentice-weighted Cox proportional hazard regression models were fitted by country. Risk estimates were pooled by random effects meta-analysis and heterogeneity was evaluated. Estimated mean (sd) DED was 1.5 (0.3) kcal/g among cases and subcohort members, varying across countries (range 1.4-1.7 kcal/g). After adjustment for age, sex, smoking, physical activity, alcohol intake, energy intake from beverages and misreporting of dietary intake, no association was observed between DED and T2D (HR 1.02 (95% CI: 0.93-1.13), which was consistent across countries (I(2) = 2.9%).CONCLUSIONS/SIGNIFICANCEIn this large European case-cohort study no association between DED of solid and semi-solid foods and risk of T2D was observed. However, despite the fact that there currently is no conclusive evidence for an association between DED and T2DM risk, choosing low energy dense foods should be promoted as they support current WHO recommendations to prevent chronic diseases.
PB Public Library of Science
YR 2013
FD 2013-05-16
LK http://hdl.handle.net/10668/1493
UL http://hdl.handle.net/10668/1493
LA en
NO van den Berg SW, van der A DL, Spijkerman AM, van Woudenbergh GJ, Tijhuis MJ, Amiano P, et al. The association between dietary energy density and type 2 diabetes in Europe: results from the EPIC-InterAct Study. PLoS ONE 2013; 8(5):e59947.
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 16, 2025