RT Journal Article
T1 Genome-wide assessment of Parkinson's disease in a Southern Spanish population.
A1 Bandrés-Ciga, Sara
A1 Price, Timothy Ryan
A1 Barrero, Francisco Javier
A1 Escamilla-Sevilla, Francisco
A1 Pelegrina, Javier
A1 Arepalli, Sampath
A1 Hernández, Dena
A1 Gutiérrez, Blanca
A1 Cervilla, Jorge
A1 Rivera, Margarita
A1 Rivera, Alberto
A1 Ding, Jing-Hui
A1 Vives, Francisco
A1 Nalls, Michael
A1 Singleton, Andrew
A1 Durán, Raquel
K1 GWAS
K1 Genetics
K1 Parkinson's disease
K1 Southern Spain
AB Here, we set out to study the genetic architecture of Parkinson's disease (PD) through a Genome-Wide Association Study in a Southern Spanish population. About 240 PD cases and 192 controls were genotyped on the NeuroX array. We estimated genetic variation associated with PD risk and age at onset (AAO). Risk profile analyses for PD and AAO were performed using a weighted genetic risk score. Total heritability was estimated by genome-wide complex trait analysis. Rare variants were screened with single-variant and burden tests. We also screened for variation in known PD genes. Finally, we explored runs of homozygosity and structural genomic variations. We replicate PD association (uncorrected p-value
YR 2016
FD 2016-06-11
LK http://hdl.handle.net/10668/10253
UL http://hdl.handle.net/10668/10253
LA en
DS RISalud
RD May 11, 2025