RT Journal Article
T1 Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
A1 Ellinghaus, David
A1 Degenhardt, Frauke
A1 Bujanda, Luis
A1 Buti, Maria
A1 Albillos, Agustin
A1 Invernizzi, Pietro
A1 Fernandez, Javier
A1 Prati, Daniele
A1 Baselli, Guido
A1 Asselta, Rosanna
A1 Grimsrud, Marit M
A1 Milani, Chiara
A1 Aziz, Fatima
A1 Kässens, Jan
A1 May, Sandra
A1 Wendorff, Mareike
A1 Wienbrandt, Lars
A1 Uellendahl-Werth, Florian
A1 Zheng, Tenghao
A1 Yi, Xiaoli
A1 de-Pablo, Raul
A1 Chercoles, Adolfo G
A1 Palom, Adriana
A1 Garcia-Fernandez, Alba-Estela
A1 Rodriguez-Frias, Francisco
A1 Zanella, Alberto
A1 Bandera, Alessandra
A1 Protti, Alessandro
A1 Aghemo, Alessio
A1 Lleo, Ana
A1 Biondi, Andrea
A1 Caballero-Garralda, Andrea
A1 Gori, Andrea
A1 Tanck, Anja
A1 Carreras-Nolla, Anna
A1 Latiano, Anna
A1 Fracanzani, Anna Ludovica
A1 Peschuck, Anna
A1 Julia, Antonio
A1 Pesenti, Antonio
A1 Voza, Antonio
A1 Jimenez, David
A1 Mateos, Beatriz
A1 Nafria-Jimenez, Beatriz
A1 Quereda, Carmen
A1 Paccapelo, Cinzia
A1 Gassner, Christoph
A1 Angelini, Claudio
A1 Cea, Cristina
A1 Solier, Aurora
A1 Pestaña, David
A1 Muñiz-Diaz, Eduardo
A1 Sandoval, Elena
A1 Paraboschi, Elvezia M
A1 Navas, Enrique
A1 Garcia-Sanchez, Felix
A1 Ceriotti, Ferruccio
A1 Martinelli-Boneschi, Filippo
A1 Peyvandi, Flora
A1 Blasi, Francesco
A1 Tellez, Luis
A1 Blanco-Grau, Albert
A1 Hemmrich-Stanisak, Georg
A1 Grasselli, Giacomo
A1 Costantino, Giorgio
A1 Cardamone, Giulia
A1 Foti, Giuseppe
A1 Aneli, Serena
A1 Kurihara, Hayato
A1 ElAbd, Hesham
A1 My, Ilaria
A1 Galvan-Femenia, Ivan
A1 Martín, Javier
A1 Erdmann, Jeanette
A1 Ferrusquia-Acosta, Jose
A1 Garcia-Etxebarria, Koldo
A1 Izquierdo-Sanchez, Laura
A1 Bettini, Laura R
A1 Sumoy, Lauro
A1 Terranova, Leonardo
A1 Moreira, Leticia
A1 Santoro, Luigi
A1 Scudeller, Luigia
A1 Mesonero, Francisco
A1 Roade, Luisa
A1 Rühlemann, Malte C
A1 Schaefer, Marco
A1 Carrabba, Maria
A1 Riveiro-Barciela, Mar
A1 Figuera-Basso, Maria E
A1 Valsecchi, Maria G
A1 Hernandez-Tejero, Maria
A1 Acosta-Herrera, Marialbert
A1 D'Angio, Mariella
A1 Baldini, Marina
A1 Cazzaniga, Marina
A1 Schulzky, Martin
A1 Cecconi, Maurizio
A1 Wittig, Michael
A1 Ciccarelli, Michele
A1 Rodriguez-Gandia, Miguel
A1 Bocciolone, Monica
A1 Miozzo, Monica
A1 Montano, Nicola
A1 Braun, Nicole
A1 Sacchi, Nicoletta
A1 Martinez, Nilda
A1 Özer, Onur
A1 Palmieri, Orazio
A1 Faverio, Paola
A1 Preatoni, Paoletta
A1 Bonfanti, Paolo
A1 Omodei, Paolo
A1 Tentorio, Paolo
A1 Castro, Pedro
A1 Rodrigues, Pedro M
A1 Blandino-Ortiz, Aaron
A1 de-Cid, Rafael
A1 Ferrer, Ricard
A1 Gualtierotti, Roberta
A1 Nieto, Rosa
A1 Goerg, Siegfried
A1 Badalamenti, Salvatore
A1 Marsal, Sara
A1 Matullo, Giuseppe
A1 Pelusi, Serena
A1 Juzenas, Simonas
A1 Aliberti, Stefano
A1 Monzani, Valter
A1 Moreno, Victor
A1 Wesse, Tanja
A1 Lenz, Tobias L
A1 Pumarola, Tomas
A1 Rimoldi, Valeria
A1 Bosari, Silvano
A1 Albrecht, Wolfgang
A1 Peter, Wolfgang
A1 Romero-Gomez, Manuel
A1 D'Amato, Mauro
A1 Duga, Stefano
A1 Banales, Jesus M
A1 Hov, Johannes R
A1 Folseraas, Trine
A1 Valenti, Luca
A1 Franke, Andre
A1 Karlsen, Tom H
K1 Coronavirus
K1 Genetics General
K1 Infectious Disease General
K1 Pulmonary/Critical Care General
K1 Viral Infections
AB There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19.We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure ) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe . After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single- nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels.We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P<5×10−8) in the meta-analysis of the two case–control panels ( odds ratio , 1.77; 95% confidence interval [CI], 1.48 to 2.11; P=1.15×10−10; and odds ratio , 1.32; 95% CI, 1.20 to 1.47; P=4.95×10−8, respectively). At locus 3p21.31, the association signal spanned the genes  SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6 and XCR1. The association signal at locus 9q34.2 coincided with the ABO  blood group locus; in this cohort, a blood -group–specific analysis showed a higher risk in blood group A than in other blood groups ( odds ratio , 1.45; 95% CI, 1.20 to 1.75; P=1.48×10−4) and a protective effect in blood group O as compared with other blood groups ( odds ratio , 0.65; 95% CI, 0.53 to 0.79; P=1.06×10−5).We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system . 
PB Massachusetts Medical Society
YR 2020
FD 2020-10-15
LK http://hdl.handle.net/10668/15770
UL http://hdl.handle.net/10668/15770
LA en
NO Severe Covid-19 GWAS Group; Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, et al. Genomewide Association Study of Severe Covid-19 with Respiratory Failure. N Engl J Med. 2020 Oct 15;383(16):1522-1534.
DS RISalud
RD Jun 1, 2025