RT Journal Article
T1 Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats.
A1 Castilla-Ortega, Estela
A1 Escuredo, Leticia
A1 Bilbao, Ainhoa
A1 Pedraza, Carmen
A1 Orio, Laura
A1 Estivill-Torrús, Guillermo
A1 Santín, Luis J
A1 Rodríguez de Fonseca, Fernando
A1 Pavón, Francisco Javier
K1 receptores de ácidos lisofosfatídicos
K1 Conducta animal
K1 Depresión
K1 Ratas
K1 Ansiedad
K1 Evaluación nutricional
K1 Aprendizaje por laberinto
K1 Natación
K1 Inmunohistoquímica
AB The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression.
PB Public Library of Science
YR 2014
FD 2014-01-07
LK http://hdl.handle.net/10668/1611
UL http://hdl.handle.net/10668/1611
LA en
NO Castilla-Ortega E, Escuredo L, Bilbao A, Pedraza C, Orio L, Estivill-Torrús G, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS ONE; 9(1):e85348
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 9, 2025