RT Journal Article
T1 Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
A1 Christakoudi, Sofia
A1 Pagoni, Panagiota
A1 Ferrari, Pietro
A1 Cross, Amanda J
A1 Tzoulaki, Ioanna
A1 Muller, David C
A1 Weiderpass, Elisabete
A1 Freisling, Heinz
A1 Murphy, Neil
A1 Dossus, Laure
A1 Turzanski Fortner, Renee
A1 Agudo, Antonio
A1 Overvad, Kim
A1 Perez-Cornago, Aurora
A1 Key, Timothy J
A1 Brennan, Paul
A1 Johansson, Mattias
A1 Tjønneland, Anne
A1 Halkjaer, Jytte
A1 Boutron-Ruault, Marie-Christine
A1 Artaud, Fanny
A1 Severi, Gianluca
A1 Kaaks, Rudolf
A1 Schulze, Matthias B
A1 Bergmann, Manuela M
A1 Masala, Giovanna
A1 Grioni, Sara
A1 Simeon, Vittorio
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Skeie, Guri
A1 Rylander, Charlotta
A1 Borch, Kristin Benjaminsen
A1 Quirós, J Ramón
A1 Rodriguez-Barranco, Miguel
A1 Chirlaque, Maria-Dolores
A1 Ardanaz, Eva
A1 Amiano, Pilar
A1 Drake, Isabel
A1 Stocks, Tanja
A1 Häggström, Christel
A1 Harlid, Sophia
A1 Ellingjord-Dale, Merete
A1 Riboli, Elio
A1 Tsilidis, Konstantinos K
K1 BMI change
K1 cancer
K1 middle adulthood
K1 weight gain
K1 weight loss
AB Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (±0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
YR 2020
FD 2020-11-09
LK http://hdl.handle.net/10668/16392
UL http://hdl.handle.net/10668/16392
LA en
DS RISalud
RD Apr 18, 2025