RT Journal Article
T1 Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol
A1 Medina-Vera, Dina
A1 Navarro, Juan Antonio
A1 Tovar, Rubén
A1 Rosell-Valle, Cristina
A1 Gutiérrez-Adan, Alfonso
A1 Ledesma, Juan Carlos
A1 Sanjuan, Carlos
A1 Pavón, Francisco Javier
A1 Baixeras, Elena
A1 Rodríguez de Fonseca, Fernando
A1 Decara, Juan
K1 Inositol
K1 D-Pinitol
K1 Insulin resistance
K1 Hypothalamus
K1 PI3K/Akt pathway
K1 Resistencia a la insulina
K1 Hipotálamo
K1 Fosfatidilinositol 3-quinasas
K1 Proteínas proto-oncogénicas c-akt
K1 Ratas
AB D-Pinitol (DPIN) is a natural occurring inositol capable of activating the insulin pathway in peripheral tissues, whereas this has not been thoroughly studied in the central nervous system. The present study assessed the potential regulatory effects of DPIN on the hypothalamic insulin signaling pathway. To this end we investigated the Phosphatidylinositol-3-kinase (PI3K)/Protein Kinase B (Akt) signaling cascade in a rat model following oral administration of DPIN. The PI3K/Akt-associated proteins were quantified by Western blot in terms of phosphorylation and total expression. Results indicate that the acute administration of DPIN induced time-dependent phosphorylation of PI3K/Akt and its related substrates within the hypothalamus, indicating an activation of the insulin signaling pathway. This profile is consistent with DPIN as an insulin sensitizer since we also found a decrease in the circulating concentration of this hormone. Overall, the present study shows the pharmacological action of DPIN in the hypothalamus through the PI3K/Akt pathway when giving in fasted animals. These findings suggest that DPIN might be a candidate to treat brain insulin-resistance associated disorders by activating insulin response beyond the insulin receptor.
PB MDPI
YR 2021
FD 2021-06-30
LK http://hdl.handle.net/10668/3750
UL http://hdl.handle.net/10668/3750
LA en
NO Medina-Vera D, Navarro JA, Tovar R, Rosell-Valle C, Gutiérrez-Adan A, Ledesma JC, et al. J. Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol. Nutrients. 2021 Jun 30;13(7):2268
DS RISalud
RD Apr 9, 2025