RT Generic
T1 Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress.
A1 Alonso-Piñeiro, Jose Angel
A1 Gonzalez-Rovira, Almudena
A1 Sánchez-Gomar, Ismael
A1 Moreno, Juan Antonio
A1 Durán-Ruiz, Ma Carmen
K1 Nrf2
K1 atherosclerosis
K1 heme oxygenase-1
K1 oxidative stress
K1 Nrf2
K1 Atherosclerosis
K1 Heme oxygenase-1
K1 Oxidative stress
AB Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties.
PB MDPI
SN 2076-3921
YR 2021
FD 2021-09-14
LK https://hdl.handle.net/10668/28353
UL https://hdl.handle.net/10668/28353
LA en
NO Alonso-Piñeiro JA, Gonzalez-Rovira A, Sánchez-Gomar I, Moreno JA, Durán-Ruiz MC. Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress. Antioxidants (Basel). 2021;10(9):1463. Published 2021 Sep 14.
NO ThisresearchwasfundedbytheInstituteofHealthCarlosIII,ISCIII(PI16-00784PI17/00130, PI20/00375, and PI20-00716), Spanish Biomedical Research Center in Cardiovascular Diseases (CIBERCV), Spanish Ministry of Science and Innovation (RYC-2017-22369), Spanish Society of Nephrology (SEN), Consejería de Salud y Familias-FEDER, Junta de Andalucía (PIGE-0052-2020), andthe ProgramaOperativo de Andalucia-FEDER, Iniciativa Territorial Integrada ITI 2014-2020, Consejería de Salud, Junta de Andalucía (PI0026-2017), co-funded by European Regional Development Fund. A waytomakeEurope.
DS RISalud
RD Sep 16, 2025