TY - JOUR AU - González-Andrades, Miguel AU - Mata, Rosario AU - González-Gallardo, María del Carmen AU - Medialdea, Santiago AU - Arias-Santiago, Salvador AU - Martínez-Atienza, Juliana AU - Ruiz-García, Antonio AU - Pérez-Fajardo, Lorena AU - Lizana-Moreno, Antonio AU - Garzón, Ingrid AU - Campos, Antonio AU - Alaminos, Miguel AU - Carmona, Gloria AU - Cuende, Natividad PY - 2017 DO - 10.1136/bmjopen-2017-016487 UR - http://hdl.handle.net/10668/3114 T2 - BMJ open AB - IntroductionThere is a need to find alternatives to the use of human donor corneas in transplants because of the limited availability of donor organs, the incidence of graft complications, as well as the inability to successfully perform corneal... LA - en PB - BMJ Publishing Group KW - Corneal transplantation KW - Corneal ulcer KW - Stromal fibrosis KW - Limbal stem cell deficiency KW - Tissue bioengineering KW - Randomized controlled trial KW - Transplante de córnea KW - Úlcera de la cornea KW - Ingeniería de tejidos KW - Ensayo clínico controlado aleatorio KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies KW - Medical Subject Headings::Diseases::Eye Diseases::Corneal Diseases KW - Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Fibroblasts::Corneal Keratocytes KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Tissue Transplantation::Corneal Transplantation KW - Medical Subject Headings::Anatomy::Tissues::Epithelium::Epithelium, Corneal KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Pilot Projects KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Culture Techniques::Cell Engineering::Tissue Engineering KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome TI - A study protocol for a multicentre randomised clinical trial evaluating the safety and feasibility of a bioengineered human allogeneic nanostructured anterior cornea in patients with advanced corneal trophic ulcers refractory to conventional treatment TY - research article ER -