TY  - JOUR
AU  - Olmedo-Pelayo, Joaquin
AU  - Rubio-Contreras, Diana
AU  - Gomez-Herreros, Fernando
PY  - 2020
DO  - 10.1093/nar/gkaa640
UR  - http://hdl.handle.net/10668/16043
T2  - Nucleic acids research
AB  - DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer drugs that poison the DNA-TOP2...
LA  - en
PB  - Oxford University Press
KW  - DNA
KW  - DNA Damage
KW  - DNA Topoisomerases, Type II
KW  - Genomic Instability
KW  - Humans
KW  - Transcription Factors
KW  - DNA Breaks, Double-Stranded
KW  - DNA End-Joining Repair
KW  - DNA-Binding Proteins
KW  - Homologous Recombination
KW  - Mutagenesis
KW  - Translocation, Genetic
TI  - Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity.
TY  - research article
VL  - 48
ER  -