RT Journal Article
T1 Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices.
A1 Lillo-Castellano, José María
A1 González-Ferrer, Juan José
A1 Marina-Breysse, Manuel
A1 Martínez-Ferrer, José Bautista
A1 Pérez-Álvarez, Luisa
A1 Alzueta, Javier
A1 Martínez, Juan Gabriel
A1 Rodríguez, Aníbal
A1 Rodríguez-Pérez, Juan Carlos
A1 Anguera, Ignasi
A1 Viñolas, Xavier
A1 García-Alberola, Arcadio
A1 Quintanilla, Jorge G
A1 Alfonso-Almazán, José Manuel
A1 García, Javier
A1 Borrego, Luis
A1 Cañadas-Godoy, Victoria
A1 Pérez-Castellano, Nicasio
A1 Pérez-Villacastín, Julián
A1 Jiménez-Díaz, Javier
A1 Jalife, José
A1 Filgueiras-Rama, David
K1 Atrial fibrillation
K1 Atrial fibrillation progression
K1 Electrical remodeling
K1 Implantable cardioverter-defibrillator
K1 Mobile health
K1 Telemedicine
K1 eHealth
AB Atrial electrical remodelling (AER) is a transitional period associated with the progression and long-term maintenance of atrial fibrillation (AF). We aimed to study the progression of AER in individual patients with implantable devices and AF episodes. Observational multicentre study (51 centres) including 4618 patients with implantable cardioverter-defibrillator +/-resynchronization therapy (ICD/CRT-D) and 352 patients (2 centres) with pacemakers (median follow-up: 3.4 years). Atrial activation rate (AAR) was quantified as the frequency of the dominant peak in the signal spectrum of AF episodes with atrial bipolar electrograms. Patients with complete progression of AER, from paroxysmal AF episodes to electrically remodelled persistent AF, were used to depict patient-specific AER slopes. A total of 34 712 AF tracings from 830 patients (87 with pacemakers) were suitable for the study. Complete progression of AER was documented in 216 patients (16 with pacemakers). Patients with persistent AF after completion of AER showed ∼30% faster AAR than patients with paroxysmal AF. The slope of AAR changes during AF progression revealed patient-specific patterns that correlated with the time-to-completion of AER (R2 = 0.85). Pacemaker patients were older than patients with ICD/CRT-Ds (78.3 vs. 67.2 year olds, respectively, P  The AF progression shows patient-specific patterns of AER, which can be estimated using available remote-monitoring technology.
YR 2020
FD 2020
LK http://hdl.handle.net/10668/14835
UL http://hdl.handle.net/10668/14835
LA en
DS RISalud
RD Apr 7, 2025