RT Journal Article
T1 The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019.
A1 Castelpietra, Giulio
A1 Knudsen, Ann Kristin Skrindo
A1 Agardh, Emilie E
A1 Armocida, Benedetta
A1 Beghi, Massimiliano
A1 Iburg, Kim Moesgaard
A1 Logroscino, Giancarlo
A1 Ma, Rui
A1 Starace, Fabrizio
A1 Steel, Nicholas
A1 Addolorato, Giovanni
A1 Andrei, Catalina Liliana
A1 Andrei, Tudorel
A1 Ayuso-Mateos, Jose L
A1 Banach, Maciej
A1 Bärnighausen, Till Winfried
A1 Barone-Adesi, Francesco
A1 Bhagavathula, Akshaya Srikanth
A1 Carvalho, Felix
A1 Carvalho, Márcia
A1 Chandan, Joht Singh
A1 Chattu, Vijay Kumar
A1 Couto, Rosa A S
A1 Cruz-Martins, Natália
A1 Dargan, Paul I
A1 Deuba, Keshab
A1 da Silva, Diana Dias
A1 Fagbamigbe, Adeniyi Francis
A1 Fernandes, Eduarda
A1 Ferrara, Pietro
A1 Fischer, Florian
A1 Gaal, Peter Andras
A1 Gialluisi, Alessandro
A1 Haagsma, Juanita A
A1 Haro, Josep Maria
A1 Hasan, M Tasdik
A1 Hasan, Syed Shahzad
A1 Hostiuc, Sorin
A1 Iacoviello, Licia
A1 Iavicoli, Ivo
A1 Jamshidi, Elham
A1 Jonas, Jost B
A1 Joo, Tamas
A1 Jozwiak, Jacek Jerzy
A1 Katikireddi, Srinivasa Vittal
A1 Kauppila, Joonas H
A1 Khan, Moien A B
A1 Kisa, Adnan
A1 Kisa, Sezer
A1 Kivimäki, Mika
A1 Koly, Kamrun Nahar
A1 Koyanagi, Ai
A1 Kumar, Manasi
A1 Lallukka, Tea
A1 Langguth, Berthold
A1 Ledda, Caterina
A1 Lee, Paul H
A1 Lega, Ilaria
A1 Linehan, Christine
A1 Loureiro, Joana A
A1 Madureira-Carvalho, Áurea M
A1 Martinez-Raga, Jose
A1 Mathur, Manu Raj
A1 McGrath, John J
A1 Mechili, Enkeleint A
A1 Mentis, Alexios-Fotios A
A1 Mestrovic, Tomislav
A1 Miazgowski, Bartosz
A1 Mirica, Andreea
A1 Mirijello, Antonio
A1 Moazen, Babak
A1 Mohammed, Shafiu
A1 Mulita, Francesk
A1 Nagel, Gabriele
A1 Negoi, Ionut
A1 Negoi, Ruxandra Irina
A1 Nwatah, Vincent Ebuka
A1 Padron-Monedero, Alicia
A1 Panda-Jonas, Songhomitra
A1 Pardhan, Shahina
A1 Pasovic, Maja
A1 Patel, Jay
A1 Petcu, Ionela-Roxana
A1 Pinheiro, Marina
A1 Pollok, Richard Charles G
A1 Postma, Maarten J
A1 Rawaf, David Laith
A1 Rawaf, Salman
A1 Romero-Rodríguez, Esperanza
A1 Ronfani, Luca
A1 Sagoe, Dominic
A1 Sanmarchi, Francesco
A1 Schaub, Michael P
A1 Sharew, Nigussie Tadesse
A1 Shiri, Rahman
A1 Shokraneh, Farhad
A1 Sigfusdottir, Inga Dora
A1 Silva, João Pedro
A1 Silva, Renata
A1 Socea, Bogdan
A1 Szócska, Miklós
A1 Tabarés-Seisdedos, Rafael
A1 Torrado, Marco
A1 Tovani-Palone, Marcos Roberto
A1 Vasankari, Tommi Juhani
A1 Veroux, Massimiliano
A1 Viner, Russell M
A1 Werdecker, Andrea
A1 Winkler, Andrea Sylvia
A1 Hay, Simon I
A1 Ferrari, Alize J
A1 Naghavi, Mohsen
A1 Allebeck, Peter
A1 Monasta, Lorenzo
K1 Europe
K1 Mental disorders
K1 Mental health
K1 Self-harm
K1 Substance use
K1 Young people
AB Mental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends in the health status of populations and changes in the leading causes of disease burden over time. Prevalence, incidence, Years Lived with Disability (YLDs) and Years of Life Lost (YLLs) from mental disorders (MDs), substance use disorders (SUDs) and self-harm were estimated for young people aged 10-24 years in 31 European countries. Rates per 100,000 population, percentage changes in 1990-2019, 95% Uncertainty Intervals (UIs), and correlations with Sociodemographic Index (SDI), were estimated. In 2019, rates per 100,000 population were 16,983 (95% UI 12,823 - 21,630) for MDs, 3,891 (3,020 - 4,905) for SUDs, and 89·1 (63·8 - 123·1) for self-harm. In terms of disability, anxiety contributed to 647·3 (432-912·3) YLDs, while in terms of premature death, self-harm contributed to 319·6 (248·9-412·8) YLLs, per 100,000 population. Over the 30 years studied, YLDs increased in eating disorders (14·9%;9·4-20·1) and drug use disorders (16·9%;8·9-26·3), and decreased in idiopathic developmental intellectual disability (-29·1%;23·8-38·5). YLLs decreased in self-harm (-27·9%;38·3-18·7). Variations were found by sex, age-group and country. The burden of SUDs and self-harm was higher in countries with lower SDI, MDs were associated with SUDs. Mental health conditions represent an important burden among young people living in Europe. National policies should strengthen mental health, with a specific focus on young people. The Bill and Melinda Gates Foundation.
PB The Lancet Publishing Group
YR 2022
FD 2022
LK http://hdl.handle.net/10668/22349
UL http://hdl.handle.net/10668/22349
LA en
NO Castelpietra G, Knudsen AKS, Agardh EE, Armocida B, Beghi M, Iburg KM, et al.  The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019. Lancet Reg Health Eur. 2022 Apr 1;16:100341
NO TWB€arnighausen was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. F Carvalho acknowledges support from Fundacao para a Ciencia ea Tecnologia (FCT), I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences - UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB; FCT/MCTES (Ministerio da Ci^encia, Tecnologia eEnsino Superior) through the project UIDB/50006/2020. M Carvalho acknowledges the support from FCT in the scope of the project  IDP/04378/2020 and UIDB/04378/2020 of UCIBIO and the project LA/P/0140/2020 of i4HB. J S Chandan is funded on a lectureship post by the National Institute of Health Research (NIHR) and has been awarded funds from the NIHR and the Youth Endowment Fund. S Dias da Silva acknowledges the projects UIDP/04378/2021 and UIDB/04378/2021 of the Research Unit on Applied Molecular Biosciences−UCIBIO; the project LA/P/0140/2021 of the Associate Laboratory Institute for Health and Bioeconomy−i4HB; and TOXRUN − Toxicology Research Unit, University Institute of Health Sciences, IUCS-CESPU, Portugal. A J Ferrari is supportedby a National Health and Medical Research Council Early Career Fellowship Grant APP1121516 and is employed by the Queensland Centre for Mental Health Research which receives core funding from the Queensland Department of Health. S V Katikireddi would like to acknowledge funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2) and the Scottish Government Chief Scientist Office (SPHSU17). J H Kauppila reports research grants from Sigrid Juselius Foundation and the Finnish Cancer Foundation. M Kivimaki was supported by the Wellcome Trust (221854/Z/20/Z) and the Medical Research Council, UK (MR/R024227/1, MR/S011676/1). M Kumar would like to acknowledge
DS RISalud
RD Mar 14, 2025