RT Journal Article
T1 Peritumoral immune infiltrates in primary tumours are not associated with the presence of axillary lymph node metastasis in breast cancer: a retrospective cohort study.
A1 López, Carlos
A1 Bosch-Príncep, Ramón
A1 Orero, Guifré
A1 Fontoura Balagueró, Laia
A1 Korzynska, Anna
A1 García-Rojo, Marcial
A1 Bueno, Gloria
A1 Fernández-Carrobles, Maria Del Milagro
A1 Roszkowiak, Lukasz
A1 Callau Casanova, Cristina
A1 Salvadó-Usach, M Teresa
A1 Jaén Martínez, Joaquín
A1 Gibert-Ramos, Albert
A1 Roso-Llorach, Albert
A1 Gras Navarro, Andrea
A1 Berenguer-Poblet, Marta
A1 Llobera, Montse
A1 Gil Garcia, Júlia
A1 Tomás, Bárbara
A1 Gestí, Vanessa
A1 Laine, Eeva
A1 Plancoulaine, Benoít
A1 Baucells, Jordi
A1 Lejeune, Maryléne
K1 Axillary lymph nodes
K1 Breast cancer
K1 Immune response
K1 Metastasis
K1 Peritumoral
AB The axillary lymph nodes (ALNs) in breast cancer patients are the body regions to where tumoral cells most often first disseminate. The tumour immune response is important for breast cancer patient outcome, and some studies have evaluated its involvement in ALN metastasis development. Most studies have focused on the intratumoral immune response, but very few have evaluated the peritumoral immune response. The aim of the present article is to evaluate the immune infiltrates of the peritumoral area and their association with the presence of ALN metastases. The concentration of 11 immune markers in the peritumoral areas was studied in 149 patients diagnosed with invasive breast carcinoma of no special type (half of whom had ALN metastasis at diagnosis) using tissue microarrays, immunohistochemistry and digital image analysis procedures. The differences in the concentration of the immune response of peritumoral areas between patients diagnosed with and without metastasis in their ALNs were evaluated. A multivariate logistic regression model was developed to identify the clinical-pathological variables and the peritumoral immune markers independently associated with having or not having ALN metastases at diagnosis. No statistically significant differences were found in the concentrations of the 11 immune markers between patients diagnosed with or without ALN metastases. Patients with metastases in their ALNs had a higher histological grade, more lymphovascular and perineural invasion and larger-diameter tumours. The multivariate analysis, after validation by bootstrap simulation, revealed that only tumour diameter (OR = 1.04; 95% CI [1.00-1.07]; p = 0.026), lymphovascular invasion (OR = 25.42; 95% CI [9.57-67.55]; p 
SN 2167-8359
YR 2020
FD 2020-09-02
LK http://hdl.handle.net/10668/16283
UL http://hdl.handle.net/10668/16283
LA en
DS RISalud
RD Apr 19, 2025