RT Journal Article
T1 Assessment of neuropsychological function in brain tumor treatment: a comparison of traditional neuropsychological assessment with app-based cognitive screening.
A1 Romero-Garcia, Rafael
A1 Owen, Mallory
A1 McDonald, Alexa
A1 Woodberry, Emma
A1 Assem, Moataz
A1 Coelho, Pedro
A1 Morris, Rob C
A1 Price, Stephen J
A1 Santarius, Tom
A1 Suckling, John
A1 Manly, Tom
A1 Erez, Yaara
A1 Hart, Michael G
K1 Cognitive function
K1 Glioma
K1 Neuropsychiatry
K1 Neuropsychology
K1 Neurosurgery
AB Gliomas are typically considered to cause relatively few neurological impairments. However, cognitive difficulties can arise, for example during treatment, with potential detrimental effects on quality of life. Accurate, reproducible, and accessible cognitive assessment is therefore vital in understanding the effects of both tumor and treatments. Our aim is to compare traditional neuropsychological assessment with an app-based cognitive screening tool in patients with glioma before and after surgical resection. Our hypotheses were that cognitive impairments would be apparent, even in a young and high functioning cohort, and that app-based cognitive screening would complement traditional neuropsychological assessment. Seventeen patients with diffuse gliomas completed a traditional neuropsychological assessment and an app-based touchscreen tablet assessment pre- and post-operatively. The app assessment was also conducted at 3- and 12-month follow-up. Impairment rates, mean performance, and pre- and post-operative changes were compared using standardized Z-scores. Approximately 2-3 h of traditional assessment indicated an average of 2.88 cognitive impairments per patient, while the 30-min screen indicated 1.18. As might be expected, traditional assessment using multiple items across the difficulty range proved more sensitive than brief screening measures in areas such as memory and attention. However, the capacity of the screening app to capture reaction times enhanced its sensitivity, relative to traditional assessment, in the area of non-verbal function. Where there was overlap between the two assessments, for example digit span tasks, the results were broadly equivalent. Cognitive impairments were common in this sample and app-based screening complemented traditional neuropsychological assessment. Implications for clinical assessment and follow-up are discussed.
PB Springer
YR 2022
FD 2022-08
LK http://hdl.handle.net/10668/20341
UL http://hdl.handle.net/10668/20341
LA en
NO Romero-Garcia R, Owen M, McDonald A, Woodberry E, Assem M, Coelho P, et al. Assessment of neuropsychological function in brain tumor treatment: a comparison of traditional neuropsychological assessment with app-based cognitive screening. Acta Neurochir (Wien). 2022 Aug;164(8):2021-2034.
DS RISalud
RD Apr 9, 2025