RT Journal Article T1 Outpatient Parenteral Antibiotic Treatment vs Hospitalization for Infective Endocarditis: Validation of the OPAT-GAMES Criteria. A1 Pericàs, Juan M A1 Llopis, Jaume A1 Muñoz, Patricia A1 González-Ramallo, Víctor A1 García-Leoni, M Eugenia A1 de Alarcón, Arístides A1 Luque, Rafael A1 Fariñas, M Carmen A1 Goenaga, Miguel Á A1 Hernández-Meneses, Marta A1 Nicolás, David A1 Ramos-Martínez, Antonio A1 Rodríguez-Esteban, M Ángeles A1 Villoslada-Gelabert, Aroa A1 Miró, José M A1 GAMES Investigators, K1 infective endocarditis K1 mortality K1 outpatient parenteral antibiotic treatment K1 readmission K1 recurrences AB Outpatient parenteral antibiotic treatment (OPAT) programs are increasingly used to manage infective endocarditis (IE), but current criteria for indicating OPAT are markedly conservative. We aimed to investigate whether more liberal criteria for indicating OPAT in IE can be safely used. This was a prospective multicenter nationwide cohort study (2008-2018). Rates of readmission, recurrences, and 1-year mortality were compared between hospital-based antibiotic treatment (HBAT) and OPAT. Risk factors for readmission and mortality in OPAT patients were investigated by logistic regression. Patients did not fulfill OPAT-GAMES (Grupos de Apoyo al Manejo de la Endocarditis en ESpaña) criteria if they had any of the following: cirrhosis, severe central nervous system emboli, undrained abscesses, severe conditions requiring cardiac surgery in nonoperable patients, severe postsurgical complications, highly difficult-to-treat microorganisms, or intravenous drug use. A total of 2279 HBAT patients and 1268 OPAT patients were included. Among OPAT patients, 307 (24.2%) did not fulfill OPAT-GAMES criteria. Overall, OPAT patients presented higher rates of readmission than HBAT patients (18.2% vs 14.4%; P = .004), but no significant differences were found in the propensity analysis. Patients not fulfilling OPAT-GAMES criteria presented significantly higher rates of readmission than HBAT and OPAT-GAMES (23.8%, 14.4%, 16.4%; P  OPAT-GAMES criteria allow identification of IE patients at higher risk of long-term complications to whom OPAT cannot be safely administered. SN 2328-8957 YR 2022 FD 2022-08-30 LK http://hdl.handle.net/10668/19826 UL http://hdl.handle.net/10668/19826 LA en DS RISalud RD Apr 11, 2025