RT Generic
T1 Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases
A1 Plaza-Diaz, Julio
A1 Javier Ruiz-Ojeda, Francisco
A1 Gil-Campos, Mercedes
A1 Gil, Angel
K1 probiotics
K1 pediatric gastrointestinal infection
K1 mechanism of action
K1 intestinal microbiota
K1 immune system
K1 Lactobacillus-rhamnosus gg
K1 Helicobacter-pylori infection
K1 Respiratory-tract infections
K1 Long-term safety
K1 Day-care-centers
K1 Double-blind
K1 Necrotizing enterocolitis
K1 Acute gastroenteritis
K1 Prophylactic probiotics
K1 Bacterial-colonization
AB The pediatric population is continually at risk of developing infectious and inflammatory diseases. The treatment for infections, particularly gastrointestinal conditions, focuses on oral or intravenous rehydration, nutritional support and, in certain case, antibiotics. Over the past decade, the probiotics and synbiotics administration for the prevention and treatment of different acute and chronic infectious diseases has dramatically increased. Probiotic microorganisms are primarily used as treatments because they can stimulate changes in the intestinal microbial ecosystem and improve the immunological status of the host. The beneficial impact of probiotics is mediated by different mechanisms. These mechanisms include the probiotics' capacity to increase the intestinal barrier function, to prevent bacterial transferation and to modulate inflammation through immune receptor cascade signaling, as well as their ability to regulate the expression of selected host intestinal genes. Nevertheless, with respect to pediatric intestinal diseases, information pertaining to these key mechanisms of action is scarce, particularly for immune-mediated mechanisms of action. In the present work, we review the biochemical and molecular mechanisms of action of probiotics and synbiotics that affect the immune system.
PB Mdpi
SN 2072-6643
YR 2018
FD 2018-01-01
LK http://hdl.handle.net/10668/19319
UL http://hdl.handle.net/10668/19319
LA en
DS RISalud
RD May 11, 2025