TY  - JOUR
AU  - Ruedas-Torres, Inés
AU  - Rodríguez-Gómez, Irene M.
AU  - Sánchez-Carvajal, José María
AU  - Guil-Luna, Silvia
AU  - Larenas-Muñoz, Fernanda
AU  - Pallarés, Francisco J.
AU  - Carrasco, Librado
AU  - Gómez-Laguna, Jaime
PY  - 2021
DO  - 10.3389/fimmu.2021.671743
UR  - http://hdl.handle.net/10668/3823
T2  - Frontiers in Immunology
AB  - Virulent porcine reproductive and respiratory syndrome virus (PRRSV) strains, such as the Lena strain, have demonstrated a higher thymus tropism than low virulent strains. Virulent PRRSV strains lead to severe thymus atrophy, which could be related to...
LA  - en
PB  - Frontiers
KW  - Immune checkpoints
KW  - Thymus
KW  - Immunosuppression
KW  - T-cell exhaustion
KW  - PRRSV
KW  - Timo
KW  - Inmunosupresión
KW  - Linfocitos T
KW  - Virus del síndrome respiratorio y reproductivo porcino
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Diseases::Animal Diseases::Swine Diseases::Porcine Reproductive and Respiratory Syndrome
KW  - Medical Subject Headings::Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Nidovirales::Arteriviridae::Arterivirus::Porcine respiratory and reproductive syndrome virus
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Swine
KW  - Medical Subject Headings::Anatomy::Tissues::Lymphoid Tissue::Thymus Gland
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Up-Regulation
KW  - Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Virulence
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, Differentiation, T-Lymphocyte::CTLA-4 Antigen
KW  - Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Virus Physiological Phenomena::Viral Load
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death
TI  - Up-Regulation of Immune Checkpoints in the Thymus of PRRSV-1-Infected Piglets in a Virulence-Dependent Fashion
TY  - research article
ER  -