RT Journal Article
T1 HLA-DRB1*16:01 and HLA-DQB1*05:02 Alleles Influence the Susceptibility and Progression of Cutaneous Malignant Melanoma
A1 Wang, Xu
A1 Almazan, Francisco
A1 Genaro Montoyo-Pujol, Yoel
A1 Martin-Casares, Antonia
A1 Martin, Aurelio
A1 Cabrera, Teresa
A1 Angel Lopez-Nevot, Miguel
K1 Hla class-i
K1 Prognostic-factors
K1 Italian patients
K1 Dq alleles
K1 T-cells
K1 Frequencies
K1 Expression
K1 Antigens
AB Background. The influence of HLA class I and II loci on the susceptibility to melanoma remains an area of intense debate. This study aimed to examine whether the HLA system was related to melanoma susceptibility and prognosis in a southern Spanish population. Methods. In this study, HLA class I and class II genotyping were performed using polymerase chain reaction sequence-specific oligonucleotides (PCR-SSO) in 237 Spanish melanoma patients and 636 ethnically matched controls. Data were analyzed according to the clinical characteristics of the defined subgroups. Results. Compared to the control group, DRB1 * 16:01 (4% vs. 1.3%, p = 0.001, Pc = 0.035, OR = 3.28) and DQBI * 05:02 (4.9% vs. 2%, p = 0.001, Pc = 0.017, OR = 2.54) were positivity associated with the susceptibility to melanoma. Both DRB1 * 16:01 (5.4% vs. 1.3%, p = 0.001, Pc = 0.035, OR =4.46) and DQB1 * 05:02 (6.5% vs. 2%, p = 0.001, Pc = 0.017, OR = 3.44) also showed a positive correlation with Breslow thickness >1.5 mm, most notably at an early age of diagnosis (1.5 mm, most notably at an early age of diagnosis (
PB Hindawi ltd
SN 1687-8450
YR 2021
FD 2021-09-30
LK https://hdl.handle.net/10668/26188
UL https://hdl.handle.net/10668/26188
LA en
DS RISalud
RD Apr 4, 2025