RT Journal Article
T1 Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study.
A1 Molina-Montes, Esther
A1 Rodriguez-Barranco, Miguel
A1 Ching-Lopez, Ana
A1 Artacho, Reyes
A1 Huerta, Jose Maria
A1 Amiano, Pilar
A1 Lasheras, Cristina
A1 Moreno-Iribas, Conchi
A1 Jimenez-Zabala, Ana
A1 Chirlaque, Maria-Dolores
A1 Barricarte, Aurelio
A1 Lujan-Barroso, Leila
A1 Agudo, Antonio
A1 Jakszyn, Paula
A1 Quiros, Jose Ramon
A1 Sanchez-Perez, Maria-Jose
K1 Anthropometry
K1 Chronobiology
K1 Circadian clock
K1 Diet habits
K1 Genetic association analyses
K1 Genetics
K1 Obesity
AB The circadian clock is involved in the control of daily rhythms and is related to the individual's chronotype, i.e., the morningness-eveneningness preference. Knowledge is limited on the relationship between circadian genes, chronotype, sleeping patterns, chronutrition and obesity. The aim was to explore these associations within the EPIC-Spain cohort study. There were 3183 subjects with information on twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). Their association was evaluated with: chronotype and sleeping duration/quality (assessed by questionnaires), chrononutrition (number of meals and timing of intake assessed by a diet history), and also anthropometric measures of obesity at early and late adulthood (in two points in time), such as weight and waist circumference (assessed by physical measurements). Multivariable logistic and linear regression as well as additive genetic models were applied. Odds ratios (ORs), β coefficients, and p-values corrected for multiple comparisons were estimated. Genetic risk scores (GRS) were built to test gene-outcome associations further. At nominal significance level, the variant rs2735611 (PER1 gene) was associated with a 11.6% decrease in long-term weight gain (per-allele β = -0.12), whereas three CLOCK gene variants (rs12649507, rs3749474 and rs4864548), were associated with a ∼20% decrease in waist circumference gain (per-allele β ∼ -0.19). These and other associations with body measures did not hold after multiple testing correction, except waist-to-hip ratio and rs1801260, rs2070062 and rs4580704 (CLOCK gene). Associations with chrononutrition variables, chronotype and sleep duration/quality failed to reach statistical significance. Conversely, a weighted GRS was associated with the evening/late chronotype and with all other outcomes (p  Genetic variants of some circadian clock genes could explain the link between genetic susceptibility to the individual's chronotype and obesity risk.
PB Elsevier BV
YR 2022
FD 2022-07-16
LK http://hdl.handle.net/10668/22116
UL http://hdl.handle.net/10668/22116
LA en
NO Molina-Montes E, Rodríguez-Barranco M, Ching-López A, Artacho R, Huerta JM, Amiano P, et al. Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study. Clin Nutr. 2022 Sep;41(9):1977-1990.
NO The authors are thankful to the study participants of the EPICSpain chronodiet study. We also acknowledge the collaboration ofBiobank Network of the Region of Murcia, BIOBANC-MUR, registered on the Registro Nacional de Biobancos with registrationnumber B.0000859. BIOBANC-MUR is supported by the “Institutode Salud Carlos III" (project PT20/00109), by “Instituto Murciano deInvestigacion Biosanitaria Virgen de la Arrixaca, IMIB   ” and by“Consejeria de Salud de la Comunidad Autonoma de la Regi   on de  Murcia". Also, we acknowledge the Basque Biobank, which belongsto the Basque Government, Department of Health, with registrationnumber B.0000140, and the BIOBANCO del Principado de Asturiaswith registration number B.0000827. The genotyping was performed at the Spanish National Cancer Research Centre, in theHumanGenotyping lab, a member of CeGen, PRB3 and is supportedby grant PT17/0019, of the PE IþDþi 2013e2016, funded by ISCIIIand ERDF.
DS RISalud
RD Apr 11, 2025