RT Journal Article
T1 Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
A1 Ellingjord-Dale, Merete
A1 Christakoudi, Sofia
A1 Weiderpass, Elisabete
A1 Panico, Salvatore
A1 Dossus, Laure
A1 Olsen, Anja
A1 Tjonneland, Anne
A1 Kaaks, Rudolf
A1 Schulze, Matthias B.
A1 Masala, Giovanna
A1 Gram, Inger T.
A1 Skeie, Guri
A1 Rosendahl, Ann H.
A1 Sund, Malin
A1 Key, Tim
A1 Ferrari, Pietro
A1 Gunter, Marc
A1 Heath, Alicia K.
A1 Tsilidis, Konstantinos K.
A1 Riboli, Elio
A1 Jose Sanchez, Maria
A1 Chirlaque Lopez, Maria Dolores
A1 Peppa, Eleni
A1 Trichopoulou, Antonia
A1 Martimianaki, Georgia
A1 Agudo, Antonio
A1 Santiuste, Carmen
A1 Ardanaz, Eva
A1 Amiano, Pilar
A1 Boutron-Ruault, Marie-Christine
A1 Simeon, Vittorio
A1 Berrino, Franco
A1 Tumino, Rosario
A1 Severi, Gianluca
A1 Stocks, Tanja
A1 Turzanski-Fortner, Renee
A1 Aleksandrova, Krasimira
A1 Rylander, Charlotta
A1 Aune, Dagfinn
A1 Dahm, Christina C.
K1 long-term weight change
K1 breast cancer
K1 cohort study
K1 Anthropometric measures
K1 Postmenopausal women
K1 Early adulthood
K1 Body fatness
K1 Sex steroids
K1 Validity
K1 Gain
K1 Overweight
K1 Menopause
K1 Obesity
AB Background: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.Methods: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.Results: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (+/- 2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and-progesterone-receptor-positive (ERthornPRthorn) breast cancer (HR = 1.46; 1.15-1.85).Conclusion: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer.
PB Oxford univ press
SN 0300-5771
YR 2021
FD 2021-03-23
LK https://hdl.handle.net/10668/24657
UL https://hdl.handle.net/10668/24657
LA en
DS RISalud
RD Apr 8, 2025