RT Journal Article
T1 Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
A1 Porcel-Chacon, Rocio
A1 Antunez-Fernandez, Cristina
A1 Mora-Loro, Maria
A1 Ariza-Jimenez, Ana-Belen
A1 Tapia-Ceballos, Leopoldo
A1 Jimenez-Hinojosa, Jose Manuel
A1 Lopez-Siguero, Juan Pedro
A1 Leiva-Gea, Isabel
K1 Type 1 diabetes mellitus
K1 Pediatric diabetes
K1 Continuous glucose monitoring
K1 Time in 28 range
K1 HbA1c
K1 Capillary blood glucose test
K1 Sensing technology
K1 Multicenter
K1 Management
AB Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (-6 +/- 2, p0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.
PB MDPI
YR 2021
FD 2021-10-24
LK https://hdl.handle.net/10668/25015
UL https://hdl.handle.net/10668/25015
LA en
NO Porcel-Chacón R, Antúnez-Fernández C, Mora Loro M, Ariza-Jimenez AB, Tapia Ceballos L, Jimenez Hinojosa JM, et al. Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre? J Clin Med. 2021 Oct 24;10(21):4913
DS RISalud
RD Aug 4, 2025