RT Journal Article
T1 T2 Biomarkers as Predictors of Exacerbations of Chronic Obstructive Pulmonary Disease
A1 Alcazar-Navarrete, Bernardino
A1 Manuel Diaz-Lopez, Jose
A1 Garcia-Flores, Paula
A1 Ortega-Antelo, Marina
A1 Aguilar-Cruz, Ivan
A1 Ruiz-Rodriguez, Oliverio
A1 Santiago-Diaz, Pablo
A1 Romero Palacios, Pedro Jose
K1 COPD
K1 Type 2 inflammation
K1 Biomarkers
K1 Fe NO
K1 Eosinophil
K1 Blood eosinophils
K1 Mortality
K1 Risk
AB Introduction: Type 2 (T2) biomarkers such as blood eosinophil count (BEC) and FeNO have been related to a higher risk of exacerbations in COPD. It is unknown whether combining these biomarkers could be useful in forecasting COPD exacerbations. Methods: COPD patients were enrolled in this prospective, multicenter, observational study and followed up for 1 year, during which BEC were analysed at baseline (V0) while FeNO analyses were performed at baseline (V0), 6 months (V1) and 12 months (V2). The risk of moderate or severe exacerbation during follow up was assessed by Cox regression analysis, and the predictive capacity of both measurements was assessed by ROC curves and the DeLong test. Statistical significance was assumed at P
PB Elsevier espana slu
SN 0300-2896
YR 2022
FD 2022-08-01
LK https://hdl.handle.net/10668/24872
UL https://hdl.handle.net/10668/24872
LA en
DS RISalud
RD Apr 6, 2025