TY  - JOUR
AU  - San Martin-Alonso, Marta
AU  - Soler-Oliva, María E.
AU  - García-Rubio, María
AU  - García-Muse, Tatiana
AU  - Aguilera, Andrés
PY  - 2021
DO  - 10.1038/s41467-021-24737-x
UR  - http://hdl.handle.net/10668/3470
T2  - Nature communications
AB  - Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by genome-wide analysis of conditional yeast mutants that the THO transcription complex, prevents R-loop formation in G1 and S-phase,...
LA  - en
PB  - Springer Nature
KW  - Cell Cycle
KW  - DNA Damage
KW  - DNA Helicases
KW  - Genomic Instability
KW  - Mutation
KW  - Nuclear Proteins
KW  - RNA, Fungal
KW  - Ciclo Celular
KW  - Daño del ADN
KW  - ADN Helicasas
KW  - Inestabilidad Genómica
KW  - Mutación
KW  - Proteínas Nucleares
KW  - ARN de Hongos
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Acid Anhydride Hydrolases::Adenosine Triphosphatases::DNA Helicases
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Fungal
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genomic Instability
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biological
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Nucleotidyltransferases::RNA Nucleotidyltransferases::RNA Helicases
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Fungal
KW  - Medical Subject Headings::Organisms::Eukaryota::Fungi::Ascomycota::Saccharomycetales::Saccharomyces::Saccharomyces cerevisiae
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Fungal Proteins::Saccharomyces cerevisiae Proteins
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors
TI  - Harmful R-loops are prevented via different cell cycle-specific mechanisms
TY  - research article
ER  -