RT Journal Article
T1 Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice.
A1 Sampedro-Piquero, Patricia
A1 Millón, Carmelo
A1 Moreno-Fernández, Román D
A1 García-Fernández, María
A1 Diaz-Cabiale, Zaida
A1 Santin, Luis Javier
K1 adolescence
K1 aerobic exercise
K1 alcohol
K1 behavior
K1 drinking in the dark
K1 mice
AB The binge-drinking pattern of EtOH consumption, which is frequently observed in adolescents, is known to induce several neurobehavioral alterations, but protection strategies against these impairments remain scarcely explored. We aimed to study the protective role of treadmill physical exercise on the deficits caused after repeated cycles of binge-like EtOH exposure in the cognition, motivation, exploration, and emotion of C57BL/6J mice from adolescence to adulthood. Animals were divided into four groups: control group, exercised group, EtOH group, and exercised + EtOH group (20% in tap water). The exercise was performed for 20 min, 5 days/week at 20 cm/s. Then, animals were submitted to several behavioral tasks. Compared to binge-drinking mice, the exercised + EtOH group exhibited diminished anxiolytic-related behaviors in the elevated plus-maze, enhanced exploratory activity in the open field, reduced preference for alcohol odor when another rewarding stimulus was present (social stimulus) and lower latency to start self-cleaning behaviors in the sucrose splash test. In contrast, other measurements such as habituation learning and working memory were not improved by exercise. Besides, exercise was not able to reduce alcohol consumption across the weeks. In conclusion, physical activity during adolescence and early adulthood could buffer certain neurobehavioral alterations associated with binge-drinking, despite not reducing the quantity of consumed alcohol.
SN 2076-3425
YR 2020
FD 2020-08-20
LK https://hdl.handle.net/10668/24956
UL https://hdl.handle.net/10668/24956
LA en
DS RISalud
RD Apr 6, 2025