RT Journal Article
T1 Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.
A1 Li, Chen
A1 Stoma, Svetlana
A1 Lotta, Luca A
A1 Warner, Sophie
A1 Albrecht, Eva
A1 Allione, Alessandra
A1 Arp, Pascal P
A1 Broer, Linda
A1 Buxton, Jessica L
A1 Da Silva Couto Alves, Alexessander
A1 Deelen, Joris
A1 Fedko, Iryna O
A1 Gordon, Scott D
A1 Jiang, Tao
A1 Karlsson, Robert
A1 Kerrison, Nicola
A1 Loe, Taylor K
A1 Mangino, Massimo
A1 Milaneschi, Yuri
A1 Miraglio, Benjamin
A1 Pervjakova, Natalia
A1 Russo, Alessia
A1 Surakka, Ida
A1 van der Spek, Ashley
A1 Verhoeven, Josine E
A1 Amin, Najaf
A1 Beekman, Marian
A1 Blakemore, Alexandra I
A1 Canzian, Federico
A1 Hamby, Stephen E
A1 Hottenga, Jouke-Jan
A1 Jones, Peter D
A1 Jousilahti, Pekka
A1 Mägi, Reedik
A1 Medland, Sarah E
A1 Montgomery, Grant W
A1 Nyholt, Dale R
A1 Perola, Markus
A1 Pietiläinen, Kirsi H
A1 Salomaa, Veikko
A1 Sillanpää, Elina
A1 Suchiman, H Eka
A1 van Heemst, Diana
A1 Willemsen, Gonneke
A1 Agudo, Antonio
A1 Boeing, Heiner
A1 Boomsma, Dorret I
A1 Chirlaque, Maria-Dolores
A1 Fagherazzi, Guy
A1 Ferrari, Pietro
A1 Franks, Paul
A1 Gieger, Christian
A1 Eriksson, Johan Gunnar
A1 Gunter, Marc
A1 Hägg, Sara
A1 Hovatta, Iiris
A1 Imaz, Liher
A1 Kaprio, Jaakko
A1 Kaaks, Rudolf
A1 Key, Timothy
A1 Krogh, Vittorio
A1 Martin, Nicholas G
A1 Melander, Olle
A1 Metspalu, Andres
A1 Moreno, Concha
A1 Onland-Moret, N Charlotte
A1 Nilsson, Peter
A1 Ong, Ken K
A1 Overvad, Kim
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Pedersen, Nancy L
A1 Penninx, Brenda W J H
A1 Quiros, J Ramon
A1 Jarvelin, Marjo Riitta
A1 Rodriguez-Barranco, Miguel
A1 Scott, Robert A
A1 Severi, Gianluca
A1 Slagboom, P Eline
A1 Spector, Tim D
A1 Tjonneland, Anne
A1 Trichopoulou, Antonia
A1 Tumino, Rosario
A1 Uitterlinden, André G
A1 van der Schouw, Yvonne T
A1 van Duijn, Cornelia M
A1 Weiderpass, Elisabete
A1 Denchi, Eros Lazzerini
A1 Matullo, Giuseppe
A1 Butterworth, Adam S
A1 Danesh, John
A1 Samani, Nilesh J
A1 Wareham, Nicholas J
A1 Nelson, Christopher P
A1 Langenberg, Claudia
A1 Codd, Veryan
K1 Mendelian randomisation
K1 age-related disease
K1 biological aging
K1 telomere length
AB Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) 350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
PB Cell Press
YR 2020
FD 2020-02-10
LK http://hdl.handle.net/10668/15179
UL http://hdl.handle.net/10668/15179
LA en
NO Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, et al. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020 Mar 5;106(3):389-404.
NO The ENGAGE Project was funded under the European UnionFramework 7—Health Theme (HEALTH-F4-2007- 201413). TheInterAct project received funding from the European Union (Integrated Project LSHM-CT-2006-037197 in the Framework Programme 6 of the European Community). The EPIC-CVD studywas supported by core funding from the UK Medical ResearchCouncil (MR/L003120/1), the British Heart Foundation (RG/13/13/30194; RG/18/13/33946), the European Commission Framework Programme 7 (HEALTH-F2-2012-279233), and the NationalInstitute for Health Research (Cambridge Biomedical ResearchCentre at the Cambridge University Hospitals National Health Service (NHS) Foundation Trust)[*]. C.P.N is funded by the BritishHeart Foundation (BHF). V.C., C.P.N., and N.J.S. are supportedby the National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Centre and N.J.S. holds an NIHRSenior Investigator award. Chen Li is support by a four-year Wellcome Trust PhD Studentship; C.L., L.A.L., and N.J.W. are fundedby the Medical Research Council (MC_UU_12015/1). N.J.W. isan NIHR Senior Investigator. J.D. is funded by the NIHR (SeniorInvestigator Award).[*]. *The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or theDepartment of Health and Social Care. Cohort-specific and furtheracknowledgments are given in the Supplemental Information.
DS RISalud
RD Apr 18, 2025