RT Journal Article
T1 Vegetable and fruit consumption and the risk of hormone receptor-defined breast cancer in the EPIC cohort.
A1 Emaus, Marleen J
A1 Peeters, Petra H M
A1 Bakker, Marije F
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Romieu, Isabelle
A1 Ferrari, Pietro
A1 Dossus, Laure
A1 Boutron-Ruault, Marie Christine
A1 Baglietto, Laura
A1 Fortner, Renée T
A1 Kaaks, Rudolf
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Trichopoulos, Dimitrios
A1 Masala, Giovanna
A1 Pala, Valeria
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Polidoro, Silvia
A1 Skeie, Guri
A1 Lund, Eiliv
A1 Weiderpass, Elisabete
A1 Quirós, J Ramón
A1 Travier, Noémie
A1 Sanchez-Perez, Maria-Jose
A1 Chirlaque, Maria-Dolores
A1 Ardanaz, Eva
A1 Dorronsoro, Miren
A1 Winkvist, Anna
A1 Wennberg, Maria
A1 Bueno-de-Mesquita, H Bas
A1 Khaw, Kay-Tee
A1 Travis, Ruth C
A1 Key, Timothy J
A1 Aune, Dagfinn
A1 Gunter, Marc
A1 Riboli, Elio
A1 van Gils, Carla H
K1 breast cancer
K1 estrogen receptor
K1 fruit
K1 progesterone receptor
K1 vegetables
AB The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor-negative breast cancer risk. This study aimed to investigate the association between vegetable and fruit intake and steroid hormone receptor-defined breast cancer risk. A total of 335,054 female participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were included in this study (mean ± SD age: 50.8 ± 9.8 y). Vegetable and fruit intake was measured by country-specific questionnaires filled out at recruitment between 1992 and 2000 with the use of standardized procedures. Cox proportional hazards models were stratified by age at recruitment and study center and were adjusted for breast cancer risk factors. After a median follow-up of 11.5 y (IQR: 10.1-12.3 y), 10,197 incident invasive breast cancers were diagnosed [3479 estrogen and progesterone receptor positive (ER+PR+); 1021 ER and PR negative (ER-PR-)]. Compared with the lowest quintile, the highest quintile of vegetable intake was associated with a lower risk of overall breast cancer (HRquintile 5-quintile 1: 0.87; 95% CI: 0.80, 0.94). Although the inverse association was most apparent for ER-PR- breast cancer (ER-PR-: HRquintile 5-quintile 1: 0.74; 95% CI: 0.57, 0.96; P-trend = 0.03; ER+PR+: HRquintile 5-quintile 1: 0.91; 95% CI: 0.79, 1.05; P-trend = 0.14), the test for heterogeneity by hormone receptor status was not significant (P-heterogeneity = 0.09). Fruit intake was not significantly associated with total and hormone receptor-defined breast cancer risk. This study supports evidence that a high vegetable intake is associated with lower (mainly hormone receptor-negative) breast cancer risk.
YR 2015
FD 2015-11-25
LK http://hdl.handle.net/10668/9634
UL http://hdl.handle.net/10668/9634
LA en
DS RISalud
RD Apr 11, 2025