RT Journal Article
T1 A Proposed Approach to Chronic Airway Disease (CAD) Using Therapeutic Goals and Treatable Traits: A Look to the Future.
A1 Pérez de Llano, Luis
A1 Miravitlles, Marc
A1 Golpe, Rafael
A1 Alvarez-Gutiérrez, Francisco Javier
A1 Cisneros, Carolina
A1 Almonacid, Carlos
A1 Martinez-Moragon, Eva
A1 Gonzalez-Barcala, Francisco-Javier
A1 Ramos-Barbón, David
A1 Plaza, Vicente
A1 Lopez-Campos, Jose Luis
A1 de-Torres, Juan Pablo
A1 Casanova, Ciro
A1 Garcia Rivero, Juan Luis
A1 Rodriguez Hermosa, Juan
A1 Calle Rubio, Myriam
A1 Soler-Cataluña, Juan Jose
A1 Cosio, Borja G
K1 COPD asthma overlap
K1 airflow obstruction
K1 biomarker
K1 personalised medicine
AB Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. This has generated the description of new mixed or overlapping disease phenotypes with no clear biological grounds. In this special article, a group of experts provides their perspective and proposes approaching the treatment of chronic airway disease (CAD) through the identification of a series of therapeutic goals (TG) linked to treatable traits (TT) - understood as clinical, physiological, or biological characteristics that are quantifiable using biomarkers. This therapeutic approach needs validating in a clinical trial with the strategy of identification of TG and treatment according to TT for each patient independently of their prior diagnosis.
YR 2020
FD 2020-09-04
LK http://hdl.handle.net/10668/16273
UL http://hdl.handle.net/10668/16273
LA en
DS RISalud
RD Apr 6, 2025