RT Journal Article
T1 Overview of autosomal dominant polycystic kidney disease in the south of Spain.
T2 Panorámica de la poliquistosis renal autosómica dominante en una región del sur de España.
A1 Morales García, Ana Isabel
A1 Martínez Atienza, Margarita
A1 García Valverde, María
A1 Fontes Jimenez, Juan
A1 Martínez Morcillo, Antonio
A1 Esteban de la Rosa, M Angustias
A1 de Diego Fernández, Pablo
A1 García González, Miguel
A1 Fernández Castillo, Rafael
A1 Argüelles Toledo, Irene
A1 Bravo Soto, Juan Antonio
A1 Esteban de la Rosa, Rafael
A1 en representación del Grupo de Estudio de la Enfermedad Poliquística Autosómica Dominante (GEEPAD) y la Asociación Amigos del Riñón, 
K1 Autosomal dominant polycystic kidney disease
K1 Epidemiology
K1 Epidemiología
K1 Poliquistosis
K1 Poliquistosis renal autosómica dominante
K1 Polycystic
AB Although autosomal dominant polycystic kidney disease is the most common hereditary kidney disease, available data tend to be limited to after initiation of renal replacement therapy. To ascertain an overview of autosomal dominant polycystic kidney disease within the health area of Granada in southern Spain. From January 2007 to December 2016, we collected clinical, family and demographic information about all patients with autosomal dominant polycystic kidney disease, irrespective of whether or not they were treated with RRT, in the Granada health area. The computer software SPSS 15.0 and GenoPro were used. 50.6% of the 1,107 diagnosed patients were men. 99.1% were Caucasian and 4-6 generations/family were studied. The geographical distribution was heterogeneous. There was no family history in 2.43%. The mean age of diagnosis was 34.0±17.80 years and the diagnosis was made after having offspring in 57.7% of cases. The main reason for diagnosis was family history (46.4%). The mean age of initiation of renal replacement therapy was 54.2±11.05 years. 96.3% of the deceased had some degree of renal failure at the time of death. The mean age of death was 60.9±14.10 years, the main cause of death being unknown in 33.5% of cases, followed by cardiovascular (27.8%). Cases and families were concentrated in certain geographical areas and a significant number of individuals were undiagnosed prior to cardiovascular death or diagnosed late after reproduction. Given that there is currently no curative treatment, the primary prevention strategy of preimplantation genetic diagnosis should play a leading role.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/12169
UL http://hdl.handle.net/10668/12169
LA en
LA es
DS RISalud
RD Apr 18, 2025