%0 Journal Article
%A García-Marchena, Nuria
%A Pizarro, Nieves
%A Pavón, Francisco J.
%A Martínez-Huélamo, Miriam
%A Flores-López, María
%A Requena-Ocaña, Nerea
%A Araos, Pedro
%A Silva-Peña, Daniel
%A Suárez, Juan
%A Santín, Luis J.
%A de la Torre, Rafael
%A Rodríguez de Fonseca, Fernando
%A Serrano, Antonia
%T Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients
%D 2020
%U http://hdl.handle.net/10668/3862
%X Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age/sex/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantified and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment.
%K Alcoholism
%K Patients
%K Plasma
%K Receptors, lysophosphatidic acid
%K Cognitive dysfunction
%K Alcoholismo
%K Pacientes
%K Receptores del ácido lisofosfatídico
%K Disfunción cognitiva
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