RT Journal Article
T1 Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy.
A1 Yeregui, Elena
A1 Masip, Jenifer
A1 Vilades, Consuelo
A1 Domingo, Pere
A1 Pacheco, Yolanda M
A1 Blanco, Julia
A1 Mallolas, Josep
A1 Alba, Veronica
A1 Vargas, Montserrat
A1 García-Pardo, Graciano
A1 Negredo, Eugenia
A1 Olona, Montserrat
A1 Vidal-Gonzalez, Judit
A1 Peraire, Maria
A1 Marti, Anna
A1 Reverte, Laia
A1 Gomez-Bertomeu, Frederic
A1 Leal, Manuel
A1 Vidal, Francesc
A1 Peraire, Joaquim
A1 Rull, Anna
K1 HIV
K1 adipokines
K1 antiretroviral therapy
K1 immunodiscordant response
K1 poor immune recovery
AB A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response.
PB MDPI AG
YR 2022
FD 2022-02-17
LK http://hdl.handle.net/10668/21139
UL http://hdl.handle.net/10668/21139
LA en
NO Yeregui E, Masip J, Viladés C, Domingo P, Pacheco YM, Blanco J, et al. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy. Int J Mol Sci. 2022 Feb 17;23(4):2202.
DS RISalud
RD Apr 17, 2025