RT Journal Article
T1 Multimorbidity by Patient and Tumor Factors and Time-to-Surgery Among Colorectal Cancer Patients in Spain: A Population-Based Study.
A1 Luque-Fernandez, Miguel Angel
A1 Redondo-Sanchez, Daniel
A1 Lee, Shing Fung
A1 Rodriguez-Barranco, Miguel
A1 Carmona-Garcia, Ma Carmen
A1 Marcos-Gragera, Rafael
A1 Sanchez-Perez, Maria-Jose
K1 colorectal cancer epidemiology
K1 comorbidity
K1 elderly
K1 multimorbidity
AB Cancer treatment and outcomes can be influenced by tumor characteristics, patient overall health status, and comorbidities. While previous studies have analyzed the influence of comorbidity on cancer outcomes, limited information is available regarding factors associated with the increased prevalence of comorbidities and multimorbidity among patients with colorectal cancer in Spain. This cross-sectional study obtained data from all colorectal cancer cases diagnosed in two Spanish provinces in 2011 from two population-based cancer registries and electronic health records. We calculated the prevalence of comorbidities according to patient and tumor factors, identified factors associated with an increased prevalence of comorbidity and multimorbidity, analyzed the association between comorbidities and time-to-surgery, and developed an interactive web application (https://comcor.netlify.com/). The most common comorbidities were diabetes (23.6%), chronic obstructive pulmonary disease (17.2%), and congestive heart failure (14.5%). Among all comorbidities, 52% of patients were diagnosed at more advanced stages (stage III/IV). Patients with advanced age, restricted performance status or who were disabled, obese, and smokers had a higher prevalence of multimorbidity. Patients with multimorbidity had a longer time-to-surgery than those without comorbidity (17 days, 95% confidence interval: 3-29 days). We identified a consistent pattern of factors associated with a higher prevalence of comorbidities and multimorbidity at diagnosis and an increased time-to-surgery among patients with colorectal cancer with multimorbidity in Spain. This pattern may provide insights for further etiological and preventive research and help to identify patients at a higher risk for poorer cancer outcomes and suboptimal treatment.
PB Dove Medical Press Ltd.
SN 1179-1349
YR 2019
FD 2019-12-12
LK http://hdl.handle.net/10668/15046
UL http://hdl.handle.net/10668/15046
LA en
NO Luque-Fernandez MA, Redondo-Sanchez D, Lee SF, Rodríguez-Barranco M, Carmona-García MC, Marcos-Gragera R, et al. Patient and Tumor Factors and Time-to-Surgery Among Colorectal Cancer Patients in Spain: A Population-Based Study. Clin Epidemiol. 2020 Jan 14;12:31-40.
NO MALF was supported by the Spanish National HealthInstitute Carlos III (Instituto de Salud Carlos III -ISCIII),Miguel Servet-I Investigator Grant/Award Number: CP17/00206-EU-FEDER and MJS for the AndalusianDepartment of Health, Grant Number: PI-0152/2017. Thefunders had no role in study design, data collection, andanalysis, decision to publish, or preparation of themanuscript.
DS RISalud
RD Apr 7, 2025