RT Journal Article
T1 Validation of a Spanish version of the Leicester Cough Questionnaire in cystic fibrosis.
A1 Muñoz, Gerard
A1 de Gracia, Javier
A1 Giron, Rosa
A1 Olveira, Casilda
A1 Alvarez, Antonio
A1 Buxó, Maria
A1 Birring, Surinder S
A1 Vendrell, Montserrat
K1 bronchiectasis
K1 cough
K1 cystic fibrosis
K1 quality of life
K1 respiratory disease
K1 symptoms
AB Cough is a main symptom in cystic fibrosis (CF). We aim to validate a Spanish version of the Leicester Cough Questionnaire (LCQ-Sp) to measure the impact of cough in CF bronchiectasis. A prospective longitudinal multicentre study was performed. Internal consistency and score changes over a 15-day period in stable state were assessed to analyse reliability. Concurrent validity was analysed by correlation with Saint George's Respiratory Questionnaire (SGRQ) and convergent validity by assessing the association with clinical variables. Changes in scores between stable state and the first exacerbation were assessed to analyse responsiveness. 132 patients (29.73 ± 10.52 years) were enrolled in four hospitals. Internal consistency was high for the total score and good for the three domains (Cronbach's α 0.81-0.93). The test-retest reliability showed an intraclass correlation coefficient of 0.86 for the total score. The correlation between LCQ-Sp and SGRQ scores was -0.74. The LCQ-Sp score negatively correlated with sputum volume, and the mean score decreased at the beginning of exacerbations (16.04±3.81 vs 13.91±4.29) with a large effect size. The LCQ-Sp is a reliable, repeatable and responsive instrument to assess the impact of cough in CF bronchiectasis and is responsive to change in the event of exacerbations.
YR 2021
FD 2021
LK https://hdl.handle.net/10668/24468
UL https://hdl.handle.net/10668/24468
LA en
DS RISalud
RD Apr 6, 2025