RT Journal Article
T1 Identification of Potential Targets Linked to the Cardiovascular/Alzheimer's Axis through Bioinformatics Approaches.
A1 Andujar-Vera, Francisco
A1 Garcia-Fontana, Cristina
A1 Sanabria-de la Torre, Raquel
A1 Gonzalez-Salvatierra, Sheila
A1 Martinez-Heredia, Luis
A1 Iglesias-Baena, Ivan
A1 Muñoz-Torres, Manuel
A1 Garcia-Fontana, Beatriz
K1 Alzheimer’s disease
K1 bioinformatics
K1 cardiovascular disease
K1 differentially expressed genes
K1 hubs
K1 protein–protein interaction network
AB The identification of common targets in Alzheimer's disease (AD) and cardiovascular disease (CVD) in recent years makes the study of the CVD/AD axis a research topic of great interest. Besides aging, other links between CVD and AD have been described, suggesting the existence of common molecular mechanisms. Our study aimed to identify common targets in the CVD/AD axis. For this purpose, genomic data from calcified and healthy femoral artery samples were used to identify differentially expressed genes (DEGs), which were used to generate a protein-protein interaction network, where a module related to AD was identified. This module was enriched with the functionally closest proteins and analyzed using different centrality algorithms to determine the main targets in the CVD/AD axis. Validation was performed by proteomic and data mining analyses. The proteins identified with an important role in both pathologies were apolipoprotein E and haptoglobin as DEGs, with a fold change about +2 and -2, in calcified femoral artery vs healthy artery, respectively, and clusterin and alpha-2-macroglobulin as close interactors that matched in our proteomic analysis. However, further studies are needed to elucidate the specific role of these proteins, and to evaluate its function as biomarkers or therapeutic targets.
PB MDPI AG
SN 2227-9059
YR 2022
FD 2022-02-04
LK http://hdl.handle.net/10668/20817
UL http://hdl.handle.net/10668/20817
LA en
NO Andújar-Vera F, García-Fontana C, Sanabria-de la Torre R, González-Salvatierra S, Martínez-Heredia L, Iglesias-Baena I, et al. Identification of Potential Targets Linked to the Cardiovascular/Alzheimer's Axis through Bioinformatics Approaches. Biomedicines. 2022 Feb 6;10(2):389.
NO This research was funded by Instituto de Salud Carlos III grant (PI18-00803), co-fundedby the European Regional Development Fund (FEDER) and by Junta de Andalucía grant (PI-0268-2019). In addition, C.G.-F. and S.G.-S. are funded by postdoctoral and predoctoral fellowships fromInstituto de Salud Carlos III with co-funding by FEDER (CD20/00022 and FI19/00118 respectively).R.S.d.l.T. was funded by the University of Granada with co-funding by FEDER, by grant number8110 (Research investigator call in the framework of the youth guarantee Program)
DS RISalud
RD Apr 8, 2025