%0 Journal Article
%A Scarfo, Lydia
%A Chatzikonstantinou, Thomas
%A Rigolin, Gian Matteo
%A Quaresmini, Giulia
%A Motta, Marina
%A Vitale, Candida
%A Garcia-Marco, Jose Antonio
%A Hernandez-Rivas, Jose Angel
%A Miras, Fatima
%A Baile, Monica
%A Marquet, Juan
%A Niemann, Carsten U
%A Reda, Gianluigi
%A Munir, Talha
%A Gimeno, Eva
%A Marchetti, Monia
%A Quaglia, Francesca Maria
%A Varettoni, Marzia
%A Delgado, Julio
%A Iyengar, Sunil
%A Janssens, Ann
%A Marasca, Roberto
%A Ferrari, Angela
%A Cuellar-Garcia, Carolina
%A Itchaki, Gilad
%A Špaček, Martin
%A De Paoli, Lorenzo
%A Laurenti, Luca
%A Levin, Mark-David
%A Lista, Enrico
%A Mauro, Francesca R
%A Šimkovič, Martin
%A Van Der Spek, Ellen
%A Vandenberghe, Elisabeth
%A Trentin, Livio
%A Wasik-Szczepanek, Ewa
%A Ruchlemer, Rosa
%A Bron, Dominique
%A De Paolis, Maria Rosaria
%A Del Poeta, Giovanni
%A Farina, Lucia
%A Foglietta, Myriam
%A Gentile, Massimo
%A Herishanu, Yair
%A Herold, Tobias
%A Jaksic, Ozren
%A Kater, Arnon P
%A Kersting, Sabina
%A Malerba, Lara
%A Orsucci, Lorella
%A Popov, Viola Maria
%A Sportoletti, Paolo
%A Yassin, Mohamed
%A Pocali, Barbara
%A Barna, Gabor
%A Chiarenza, Annalisa
%A Dos-Santos, Gimena
%A Nikitin, Eugene
%A Andres, Martin
%A Dimou, Maria
%A Doubek, Michael
%A Enrico, Alicia
%A Hakobyan, Yervand
%A Kalashnikova, Olga
%A Ortiz-Pareja, Macarena
%A Papaioannou, Maria
%A Rossi, Davide
%A Shah, Nimish
%A Shrestha, Amit
%A Stanca, Oana
%A Stavroyianni, Niki
%A Strugov, Vladimir
%A Tam, Constantine
%A Zdrenghea, Mihnea
%A Coscia, Marta
%A Stamatopoulos, Kostas
%A Rossi, Giuseppe
%A Rambaldi, Alessandro
%A Montserrat, Emili
%A Foa, Robin
%A Cuneo, Antonio
%A Ghia, Paolo
%T COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus.
%D 2020
%U http://hdl.handle.net/10668/15913
%X Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (≥65 years) (odds ratio 3.72 [95% CI 1.79-7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (≤12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate for severe COVID-19 was lower (p < 0.05) for patients on ibrutinib versus those on other regimens or off treatment. Of 151 patients with severe disease, 55 (36.4%) succumbed versus only 1/38 (2.6%) with mild disease; age and comorbidities did not impact on mortality. In CLL, (1) COVID-19 severity increases with age; (2) antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; (3) age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency.
%K Pyrimidines
%K Retrospective Studies
%K SARS-CoV-2
%K Severity of Illness Index
%K Surveys and Questionnaires
%~