TY  - JOUR
AU  - Kazantseva, Liliya
AU  - Becerra, José
AU  - Santos-Ruiz, Leonor
PY  - 2021
DO  - 10.1007/s43440-021-00324-1
SN  - 1734-1140
UR  - http://hdl.handle.net/10668/3408
T2  - Pharmacological Reports
AB  - Background: Doxorubicin is the chemotherapeutic drug of choice in osteosarcoma treatment, but its cumulative administration causes dilated cardiomyopathy. Combination therapy represents a potential strategy to reduce the therapeutic dosage of the...
LA  - en
PB  - Springer
KW  - Osteosarcoma
KW  - Doxorubicin
KW  - Oridonin
KW  - Synergism
KW  - Combination therapy
KW  - Cardioprotection
KW  - Doxorrubicina
KW  - Sinergismo farmacológico
KW  - Quimioterapia combinada
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Diterpenes::Diterpenes, Kaurane
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma::Osteosarcoma
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Doxorubicin
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions::Drug Synergism
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy
KW  - Medical Subject Headings::Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Lamiaceae::Isodon
KW  - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Calcium-Binding Proteins::Annexins::Annexin A5
KW  - Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Photometry::Luminescent Measurements::Fluorometry::Cytophotometry::Flow Cytometry
KW  - Medical Subject Headings::Organisms::Eukaryota::Plants::Plants, Medicinal
KW  - Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Magnetic Phenomena::Electromagnetic Phenomena::Electromagnetic Radiation::Light::Luminescence::Fluorescence
KW  - Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Cardiomyopathy, Dilated
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 3-Ring::Xanthenes
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Doxorubicin
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Electrophoresis::Blotting, Western
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Cytological Techniques::Histocytochemistry::Immunohistochemistry::Fluorescent Antibody Technique
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Subcellular Fractions::Mitochondria
KW  - Medical Subject Headings::Information Science::Information Science::Computing Methodologies::Software
TI  - Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells
TY  - research article
ER  -