RT Journal Article
T1 Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System
A1 Dopazo, Joaquín
A1 Maya-Miles, Douglas
A1 García, Federico
A1 Lorusso, Nicola
A1 Calleja, Miguel Ángel
A1 Pareja, María Jesús
A1 López-Miranda, José
A1 Rodríguez-Baño, Jesús
A1 Padillo, Javier
A1 Túnez, Isaac
A1 Romero-Gómez, Manuel
K1 Personalized medicine
K1 Precision medicine
K1 Covid-19
K1 SARS CoV2
K1 Epidemiology
K1 Host genetics
K1 Viral genome
K1 Public health
K1 Health care
K1 Vaccination
K1 Medicina de precisión
K1 Epidemiología
K1 Genoma viral
K1 Atención a la salud
K1 Vacunación
AB The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the prevention, diagnosis, treatment, surveillance and management of a new challenge in public health. COVID-19 infection is highly variable, ranging from asymptomatic infections to severe, life-threatening manifestations. Personalized medicine can play a key role in elucidating individual susceptibility to the infection as well as inter-individual variability in clinical course, prognosis and response to treatment. Integrating personalized medicine into clinical practice can also transform health care by enabling the design of preventive and therapeutic strategies tailored to individual profiles, improving the detection of outbreaks or defining transmission patterns at an increasingly local level. SARS-CoV2 genome sequencing, together with the assessment of specific patient genetic variants, will support clinical decision-makers and ultimately better ways to fight this disease. Additionally, it would facilitate a better stratification and selection of patients for clinical trials, thus increasing the likelihood of obtaining positive results. Lastly, defining a national strategy to implement in clinical practice all available tools of personalized medicine in COVID-19 could be challenging but linked to a positive transformation of the health care system. In this review, we provide an update of the achievements, promises, and challenges of personalized medicine in the fight against COVID-19 from susceptibility to natural history and response to therapy, as well as from surveillance to control measures and vaccination. We also discuss strategies to facilitate the adoption of this new paradigm for medical and public health measures during and after the pandemic in health care systems.
PB MDPI
YR 2021
FD 2021-05-26
LK http://hdl.handle.net/10668/4414
UL http://hdl.handle.net/10668/4414
LA spa
NO Dopazo J, Maya-Miles D, García F, Lorusso N, Calleja MÁ, Pareja MJ, et al. Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System. J Pers Med. 2021 May 26;11(6):475.
DS RISalud
RD Apr 5, 2025