RT Journal Article
T1 Dietary Epicatechin Is Available to Breastfed Infants through Human Breast Milk in the Form of Host and Microbial Metabolites.
A1 Khymenets, Olha
A1 Rabassa, Montserrat
A1 Rodríguez-Palmero, Maria
A1 Rivero-Urgell, Montserrat
A1 Urpi-Sarda, Mireia
A1 Tulipani, Sara
A1 Brandi, Pilar
A1 Campoy, Cristina
A1 Santos-Buelga, Celestino
A1 Andres-Lacueva, Cristina
K1 breastfeeding
K1 cocoa
K1 dietary polyphenols
K1 epicatechin host and microbiota metabolites
K1 human breast milk
AB Polyphenols play an important role in human health. To address their accessibility to a breastfed infant, we planned to evaluate whether breast milk (BM) (colostrum, transitional, and mature) epicatechin metabolites could be related to the dietary habits of mothers. The polyphenol consumption of breastfeeding mothers was estimated using a food frequency questionnaire and 24 h recalls. Solid-phase extraction-ultra performance liquid chromatography-tandem mass spectrometry (SPE-UPLC-MS/MS) was applied for direct epicatechin metabolite analysis. Their bioavailability in BM as a result of dietary ingestion was confirmed in a preliminary experiment with a single dose of dark chocolate. Several host and microbial phase II metabolites of epicatechin were detected in BM among free-living lactating mothers. Interestingly, a modest correlation between dihydroxyvalerolactone sulfate and the intake of cocoa products was observed. Although a very low percentage of dietary polyphenols is excreted in BM, they are definitely in the diet of breastfed infants. Therefore, evaluation of their role in infant health could be further promoted.
PB American Chemical Society
YR 2016
FD 2016-06-06
LK http://hdl.handle.net/10668/10165
UL http://hdl.handle.net/10668/10165
LA en
NO Khymenets O, Rabassa M, Rodríguez-Palmero M, Rivero-Urgell M, Urpi-Sarda M, Tulipani S, et al. Dietary Epicatechin Is Available to Breastfed Infants through Human Breast Milk in the Form of Host and Microbial Metabolites. J Agric Food Chem. 2016 Jul 6;64(26):5354-60
DS RISalud
RD Apr 6, 2025