TY - GEN AU - Bhatia, Vaibhav AU - Herrera-Moyano, Emilia AU - Aguilera, Andres AU - Gomez-Gonzalez, Belen PY - 2017 DO - 10.3390/genes8070171 SN - 2073-4425 UR - http://hdl.handle.net/10668/19261 T2 - Genes AB - The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) is accompanied by a DNA-RNA hybrid. Unresolved R-loops can impede transcription and replication processes and lead to genomic... LA - en PB - Mdpi ag KW - genetic instability KW - DNA-RNA hybrids KW - Fanconi anemia KW - BRCA KW - replication stress KW - cancer KW - Mediated genome instability KW - Dna-rna hybrids KW - Cancer susceptibility protein KW - Transcriptional pause sites KW - Fanconi anemia/brca pathway KW - Common fragile sites KW - Cross-link repair KW - Saccharomyces-cerevisiae KW - Fork progression KW - Rna/dna hybrids TI - The Role of Replication-Associated Repair Factors on R-Loops TY - review VL - 8 ER -