RT Journal Article
T1 Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort.
A1 Landi, Margarita
A1 Maldonado-Ficco, Hernan
A1 Perez-Alamino, Rodolfo
A1 Maldonado-Cocco, Jose A
A1 Citera, Gustavo
A1 Arturi, Pablo
A1 Sampaio-Barros, Percival D
A1 Flores Alvarado, Diana E
A1 Burgos-Vargas, Ruben
A1 Santos, Elena
A1 Palleiro, Daniel
A1 Gutierrez, Miguel A
A1 Vieyra-Sousa, Elsa
A1 Pimentel-Santos, Fernando
A1 Paira, Sergio O
A1 Berman, Alberto
A1 Barrezueta, Claudia Vera
A1 Vazquez-Mellado, Janitzia
A1 Collantes-Estevez, Eduardo
AB The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by X or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests.Primary AS was diagnosed in 1072 patients, psoriatic spondylitis in 147, and spondylitis associated to inflammatory bowel disease (IBD) in 45 patients. Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage. Dactylitis and enthesitis, as well as swollen joint count, were significantly more common among women. In primary AS, there was a marked male predominance (76.2%). Among patients with psoriatic spondylitis, male predominance was lower (57.8%), but was also associated with worse spinal mobility and more severe radiologic damage. In the total population, male patients with primary AS referred higher permanent work disability (13.2% vs 6.9%; P <0.05), although no difference was observed in psoriatic or IBD spondylitis according to the gender. Among Ibero-American SpA patients, there are some differences in clinical and radiological manifestations, men showing more structural damage, whereas women more active disease. These data suggest that the phenotype of SpA differs between genders. This can influence the subsequent diagnostic approach and therapeutic decisions.
PB Wolters Kluwer Health
YR 2016
FD 2016-11-22
LK http://hdl.handle.net/10668/10702
UL http://hdl.handle.net/10668/10702
LA en
NO Landi M, Maldonado-Ficco H, Perez-Alamino R, Maldonado-Cocco JA, Citera G, Arturi P, et al. Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort. Medicine (Baltimore). 2016 Dec;95(51):e5652
DS RISalud
RD Apr 4, 2025