RT Journal Article
T1 Transcranial Magnetic Stimulation Improves Muscle Involvement in Experimental Autoimmune Encephalomyelitis
A1 Peña-Toledo, Maria Angeles
A1 Luque, Evelio
A1 Ruz-Caracuel, Ignacio
A1 Agüera, Eduardo
A1 Jimena, Ignacio
A1 Peña-Amaro, Jose
A1 Tunez, Isaac
K1 Experimental autoimmune encephalomyelitis
K1 Multiple sclerosis
K1 Skeletal muscle
K1 Transcranial magnetic stimulation
K1 Natalizumab
K1 Oxidative stress
K1 Muscular atrophy
K1 Encefalomielitis autoinmune experimental
K1 Esclerosis múltiple
K1 Músculo esquelético
K1 Estimulación magnética transcraneal
K1 Estrés oxidativo
K1 Atrofia muscular
AB Skeletal muscle is affected in experimental autoimmune encephalomyelitis (EAE), which is a model of multiple sclerosis that produces changes including muscle atrophy; histological features of neurogenic involvement, and increased oxidative stress. In this study, we aimed to evaluate the therapeutic effects of transcranial magnetic stimulation (TMS) on the involvement of rat skeletal muscle and to compare them with those produced by natalizumab (NTZ). EAE was induced by injecting myelin oligodendrocyte glycoprotein (MOG) into Dark Agouti rats. Both treatments, NTZ and TMS, were implemented from day 15 to day 35. Clinical severity was studied, and after sacrifice, the soleus and extensor digitorum longus muscles were extracted for subsequent histological and biochemical analysis. The treatment with TMS and NTZ had a beneficial effect on muscle involvement in the EAE model. There was a clinical improvement in functional motor deficits, atrophy was attenuated, neurogenic muscle lesions were reduced, and the level of oxidative stress biomarkers was lower in both treatment groups. Compared to NTZ, the best response was obtained with TMS for all the parameters analyzed. The myoprotective effect of TMS was higher than that of NTZ. Thus, the use of TMS may be an effective strategy to reduce muscle involvement in multiple sclerosis.
PB MDPI
SN 1661-6596
YR 2021
FD 2021-08-10
LK http://hdl.handle.net/10668/4502
UL http://hdl.handle.net/10668/4502
LA en
NO Peña-Toledo MA, Luque E, Ruz-Caracuel I, Agüera E, Jimena I, Peña-Amaro J, et al. Transcranial Magnetic Stimulation Improves Muscle Involvement in Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 2021 Aug 10;22(16):8589
DS RISalud
RD Apr 6, 2025