RT Journal Article
T1 The Immune System through the Lens of Alcohol Intake and Gut Microbiota
A1 Calleja-Conde, Javier
A1 Echeverry-Alzate, Victor
A1 Bühler, Kora-Mareen
A1 Durán-González, Pedro
A1 Morales-García, Jose Ángel
A1 Segovia-Rodríguez, Lucía
A1 Rodríguez de Fonseca, Fernando
A1 Giné, Elena
A1 López-Moreno, Jose Antonio
K1 Alcohol
K1 Gut
K1 Microbiota
K1 Brain
K1 Liver
K1 Immune system
K1 Dysbiosis
K1 Microbioma gastrointestinal
K1 Encéfalo
K1 HígadoSistema inmunológico
K1 Sistema inmunológico
K1 Disbiosis
AB The human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system.
PB MDPI
YR 2021
FD 2021-07-13
LK http://hdl.handle.net/10668/3751
UL http://hdl.handle.net/10668/3751
LA en
NO Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Durán-González P, Morales-García JÁ, Segovia-Rodríguez L, et al. The Immune System through the Lens of Alcohol Intake and Gut Microbiota. Int J Mol Sci. 2021 Jul 13;22(14):7485
DS RISalud
RD Apr 11, 2025